Evidence map›Paper›PMID 40851914›Full record

ArticleFrontiers in oral health2025

Novel antimicrobial and bioactive resin-based clear aligner attachment orthodontic materials.

Heba Alqarni, Ibrahim Ba-Armah, Nader Almutairi, Mohammad Alenizy, Dwayne D Arola, Thomas W Oates, Jirun Sun, Michael D Weir, Hockin H K Xu

Abstract read
In one paragraph

Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heba AlqarniDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD, United States.
Ibrahim Ba-ArmahDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD, United States.
Nader AlmutairiDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD, United States.
Mohammad AlenizyDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD, United States.
Dwayne D ArolaMaterials Science and Engineering (MSE), University of Washington, Seattle, WA, United States.
Thomas W OatesDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland, School of Dentistry, Baltimore, MD, United States.
Jirun SunMineralized Tissue Biology Department, The ADA Forsyth Institute, Cambridge, MA, United States.
Michael D WeirDepartment of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD, United States.
Hockin H K XuDepartment of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD, United States.

Funding

Hydrolysis-resistant resin networks for durable and multifunctional dental restorationsR01DE033442 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Jirun Sun, HUAKUN XU · 2024 to 2026
$1.4M
NIDCR NIH HHS R01 DE033442
6 · The paper itself

Abstract

Introduction: Clear aligner orthodontic treatment provides a hygienic and esthetic alternative to fixed appliances; however, the required resin attachments can promote plaque accumulation and increase the risk of white-spot lesions in enamel. This study aimed to develop a novel resin-based antibacterial and bioactive orthodontic clear aligner attachment and evaluate its mechanical and antibacterial properties. Methods: A resin matrix composed of urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) was modified with 3% dimethylaminododecyl methacrylate (DMADDM) for antibacterial effects and nano-amorphous calcium phosphate (NACP) to support remineralization. Transbond™ LV and Vitremer™ were selected as commercial controls. Mechanical properties (flexural strength, elastic modulus, microhardness, and shear bond strength), degree of conversion, and antibacterial performance against Results: All experimental groups showed flexural strength of 100.6-109.2 MPa, exceeding the ISO standard for resin-based materials. Degree of conversion in experimental groups ranged from (53.4 ± 2.3 to 69 ± 0.9) %, significantly exceeding (47.5 ± 0.1) % for Transbond control ( Conclusion: This novel clear aligner attachment resin exhibits promising mechanical strength, high degree of conversion, potent antibacterial effects, and ion releases to potentially reduce white-spot lesions during clear aligner treatment.

Indexed as

antibacterialbioactive and therapeuticclear aligner attachmentdental orthodonticsnanoparticleswhite-spot lesions

Identifiers

PMID40851914
PMCPMC12367662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.