Evidence map›Paper›PMID 40851859›Full record

ArticleFrontiers in microbiology2025

Cross-matrix multi-omics profiling identifies host-microbe interactions and diagnostic signatures in bovine subclinical mastitis.

Yuqiong Li, Xiulan Xie, Youli Yu, Song Hua, ZhuMing Zhang, Zhengwei Zhao, Haihui Gao, Chenglian Zhang, Meizhou Huang

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqiong Li *Institute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, China.
Xiulan Xie *Institute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, China.
Youli YuInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, China.
Song HuaCollege of Veterinary Medicine, Northwest A&F University, Xianyang, China.
ZhuMing ZhangCollege of Animal Science and Technology, Ningxia University, Yinchuan, China.
Zhengwei ZhaoInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, China.
Haihui GaoInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, China.
Chenglian ZhangNingxia Hui Autonomous Region Animal Disease Prevention and Control Center, Yinchuan, China.
Meizhou HuangMetabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, Academician (Expert) Workstation of Sichuan Province, Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subclinical mastitis (SCM) is a widespread but frequently undetected condition in dairy cows, leading to reduced milk quality and compromised animal health. This study utilizes an integrated multi-omics strategy encompassing metabolomics and microbiome analyses to investigate the systemic effects of SCM across four biological matrices: blood, milk, feces, and rumen fluid. Our findings reveal significant alterations in hematological and biochemical parameters, with key biomarkers such as digalacturonic acid and N-ε-methyl-L-lysine indicating systemic metabolic and immune dysregulation. Metabolomic profiling uncovered distinct disease-related metabolic patterns, while 16S rRNA sequencing revealed substantial microbial shifts, particularly involving

Indexed as

biomarkersmetabolomicsmicrobiomemulti-omics approachsubclinical mastitis

Identifiers

PMID40851859
PMCPMC12369410

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.