Evidence map›Paper›PMID 40851800›Full record

ArticleFrontiers in cellular and infection microbiology2025

The AcrAB efflux pump contributes to the virulence of Enteroaggregative

Martina Laudazzi, Emily Schifano, Francesca Sivori, Ludovica Altieri, Daniela Uccelletti, Enea G Di Domenico, Bianca Colonna, Martina Pasqua, Gianni Prosseda

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martina LaudazziDepartment of Biology and Biotechnologies "Charles Darwin", Institut Pasteur in Italy, Sapienza University of Rome, Rome, Italy.
Emily SchifanoDepartment of Biology and Biotechnologies "Charles Darwin", Institut Pasteur in Italy, Sapienza University of Rome, Rome, Italy.
Francesca SivoriMicrobiology and Virology, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Ludovica AltieriInstitute of Molecular Biology and Pathology (IBPM), CNR National Research Council, Rome, Italy.
Daniela UccellettiDepartment of Biology and Biotechnologies "Charles Darwin", Institut Pasteur in Italy, Sapienza University of Rome, Rome, Italy.
Enea G Di DomenicoMicrobiology and Virology, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Bianca ColonnaDepartment of Biology and Biotechnologies "Charles Darwin", Institut Pasteur in Italy, Sapienza University of Rome, Rome, Italy.
Martina PasquaDepartment of Biology and Biotechnologies "Charles Darwin", Institut Pasteur in Italy, Sapienza University of Rome, Rome, Italy.
Gianni ProssedaDepartment of Biology and Biotechnologies "Charles Darwin", Institut Pasteur in Italy, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug efflux pumps play a major role in the emergence of antibiotic resistance. AcrAB is particularly important among them, as it is the main RND pump in

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsBacterial AdhesionEnteropathogenic Escherichia coliEscherichia coliEscherichia coli ProteinsVirulence FactorsAnimalsBiofilmsCaenorhabditis elegansEpithelial CellsEscherichia coli InfectionsGene DeletionHumansVirulenceAcrB protein, E coliATP-Binding Cassette, Sub-Family C ProteinsEscherichia coli ProteinsVirulence FactorsAcrABbacteria-host interactionsbacterial transmembrane complexesE. coli pathogensenteroaggregative Escherichia coli (EAEC)multidrug efflux pumps

Identifiers

PMID40851800
PMCPMC12367648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.