ArticleCureus2025
A Case Report of Continuous Flumazenil Infusion in a Nonagenarian With Benzodiazepine Toxicity, Managed Outside Intensive Care.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Benzodiazepine overdose in older adults with renal impairment can lead to prolonged coma and respiratory depression. Flumazenil is an available antidote, though its use in continuous infusion is rarely documented, especially in geriatric patients outside intensive care. We report the case of a 93-year-old man with chronic kidney disease and acquired solitary kidney who was admitted for acute respiratory failure secondary to aspiration pneumonia. During hospitalization, the patient developed a profound and persistent alteration of consciousness with stertorous breathing and hypotension. After a positive response to a test dose of flumazenil, a continuous infusion was started, resulting in full neurological recovery. The infusion was tapered over 72 hours without significant adverse effects. Unfortunately, the patient died as a result of sepsis caused by
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