ArticleCureus2025
Polymerized IgA Monoclonal Gammopathy Simulating Biclonal Gammopathy: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum protein electrophoresis (SPEP) typically reveals a single monoclonal (M) band in cases of monoclonal gammopathy (MG). Occasionally, two bands may appear, suggesting biclonal gammopathy. However, certain monoclonal immunoglobulins (Ig), particularly IgA, may exist in multiple polymerization states, mimicking biclonal patterns. We report the case of a patient with chronic renal failure referred for routine evaluation. SPEP revealed two monoclonal bands in the beta-2 and gamma-globulin regions, raising suspicion of biclonal gammopathy. Immunotyping (IT) identified both bands as IgA lambda, suggesting either biclonality or different polymerization states of the same monoclonal protein. To clarify, serum was treated with beta-mercaptoethanol. Post-reduction IT showed persistence of the beta-2-globulin band and disappearance of the gamma-globulin band, confirming a single IgA lambda monoclonal component with two distinct polymerization states. IgA MGs can exhibit atypical electrophoretic patterns due to variable polymerization, which may mimic biclonal patterns. In such scenarios, chemical reduction with beta-mercaptoethanol serves as a critical tool for accurate diagnosis.
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Registered trials
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