Evidence map›Paper›PMID 40851552›Full record

ArticleWomen's health (London, England)

"I became alright after birth": Mechanisms driving improvements in mental health symptoms in the postpartum transition among persons at risk for HIV in South Africa.

Katherine E Kabel, Jane H Lee, Jennifer N Githaiga, Linda Gwangqa, Madison R Fertig, Lauren R Gulbicki, Maria J Bustamante, Lucia Knight, Conall O'Cleirigh, Christina Psaros and 1 more

Abstract read
In one paragraph

Article in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Katherine E KabelDepartment of Psychological & Brain Sciences, Boston University, MA, USA.ORCID 0000-0002-1803-874X
Jane H LeeDepartment of Psychological & Brain Sciences, Boston University, MA, USA.
Jennifer N GithaigaDivision of Social and Behavioural Sciences, University of Cape Town, South Africa.
Linda GwangqaDivision of Social and Behavioural Sciences, University of Cape Town, South Africa.
Madison R FertigDepartment of Psychological & Brain Sciences, Boston University, MA, USA.
Lauren R GulbickiDepartment of Psychiatry, Massachusetts General Hospital, Boston, USA.
Maria J BustamanteDepartment of Psychological & Brain Sciences, Boston University, MA, USA.
Lucia KnightDivision of Social and Behavioural Sciences, University of Cape Town, South Africa.
Conall O'CleirighDepartment of Psychiatry, Massachusetts General Hospital, Boston, USA.
Christina PsarosDepartment of Psychiatry, Massachusetts General Hospital, Boston, USA.
Amelia M StantonDepartment of Psychological & Brain Sciences, Boston University, MA, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Reducing psychological barriers to PrEP persistence among pregnant and postpartum women in Cape Town, South AfricaK23MH131438 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Amelia M. Stanton · 2022 to 2026
$933k
NIAID NIH HHS P30 AI060354NIMH NIH HHS K23 MH131438
6 · The paper itself

Abstract

backgroundPregnant and postpartum persons (PPPs) are at increased risk for HIV acquisition, and depression and posttraumatic stress disorder (PTSD) negatively impact engagement in HIV prevention behaviors like pre-exposure prophylaxis (PrEP) use, thereby increasing risk.

objectivesThe present study explored changes in mental health symptoms from pregnancy to postpartum to inform future interventions for PPP that address mental health and HIV prevention.

designThis analysis is part of a larger, mixed-methods study conducted in South Africa that examined antenatal mental health barriers to PrEP use, employing an explanatory sequential design.

methodsParticipants recruited from an antenatal clinic were pregnant or postpartum, over 18, not on PrEP, and with no history of PrEP use. Participants first took a survey to assess depression and PTSD symptoms. Those with elevated symptoms during pregnancy completed qualitative interviews during pregnancy and postpartum. Data were analyzed via thematic analysis.

resultsOf 110 survey participants, 23 completed qualitative interviews (10 pregnancy only, 6 postpartum only, 7 both). This analysis includes 13 participants who completed either both interviews or postpartum only. Three themes illustrated processes linked to symptom reduction postpartum: (1) increased feelings of empowerment (e.g., via acceptance of life circumstances), (2) improvements in emotional and tangible support (e.g., via improved communication, increased caretaking and financial support), and (3) conceptualizations of infants and motherhood as sources of joy and motivation (e.g., pride in maternal role, companionship with baby).

conclusionThese themes highlight processes that may contribute to reductions in depression and PTSD symptoms postpartum, which could be integrated into interventions targeting mental health and HIV prevention during pregnancy. Intervention components may include skills promoting self-efficacy, problem-solving, communication, and identifying sources of joy and meaning. Interventions leveraging these mechanisms of symptom improvement during the postpartum transition may enhance mental health during pregnancy and promote greater engagement in HIV prevention behaviors.

Indexed as

DepressionDepression, PostpartumHIV InfectionsPostpartum PeriodStress Disorders, Post-TraumaticAdultFemaleHumansMental HealthPre-Exposure ProphylaxisPregnancyQualitative ResearchSouth AfricaSurveys and QuestionnairesYoung AdultHIV preventionperipartum mental healthpostnatal depressionPTSD

Identifiers

PMID40851552
PMCPMC12378541

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.