Evidence map›Paper›PMID 40851463›Full record

ReviewBioanalysis2025

How microsampling is impacting pharmacokinetic and toxicokinetic studies: volumetric absorptive microsampling (VAMS).

Michele Protti, Roberto Mandrioli, Hugo M Santos, Carlos Lodeiro, José L Capelo-Martínez, Laura Mercolini

Abstract readReview
In one paragraph

Review in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michele ProttiResearch group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Roberto MandrioliDepartment for Life Quality Studies (QuVi), Alma Mater Studiorum - University of Bologna, Rimini, Italy.
Hugo M SantosBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
Carlos LodeiroBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
José L Capelo-MartínezBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
Laura MercoliniResearch group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsampling, using minute amounts of biological specimen, is uniquely suited for carrying out human and animal pharmacokinetic and toxicokinetic studies. Indeed, it provides important advantages over common blood-drawing procedures (e.g. increased analyte stability, simpler and cheaper storage and shipping, self-sampling possibility, reduced consumption of materials and animals) while also maintaining similar performance and result reliability. In the microsampling space, volumetric absorptive microsampling (VAMS) is currently considered one of the most important and widespread technologies, thanks to its volume accuracy capabilities, making it natively suitable for quantitative analysis. In this review, an exhaustive treatment of pharmacokinetic and toxicokinetic studies using VAMS is presented, as well as several examples of analytical methods prospectively enabling the employment of VAMS for the same purpose.

Indexed as

Blood Specimen CollectionPharmacokineticsToxicokineticsAnimalsHumansDried blood spots (DBS)Microsamplingpharmacokinetics (PK)toxicokinetics (TK)volumetric absorptive microsampling (VAMS)

Identifiers

PMID40851463
PMCPMC12413049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.