Evidence map›Paper›PMID 40851454›Full record

ArticleJournal of sleep research2026

The Number of Newly Dispensed Hypnotic Drugs During the First COVID-19 Lockdown Period in The Netherlands.

Dana M Dijkgraaf, Pantea Kiani, Maureen N Zijlstra, Pauline A Hendriksen, Johan Garssen, Joris C Verster

Abstract read
In one paragraph

Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dana M DijkgraafDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.ORCID 0009-0002-2742-907X
Pantea KianiDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0003-3073-9749
Maureen N ZijlstraDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.ORCID 0009-0003-8909-4073
Pauline A HendriksenDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-9030-4432
Johan GarssenDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-8678-9182
Joris C VersterDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-6455-2096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2019 coronavirus (COVID-19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first-time dispensed hypnotic drugs during the first COVID-19 lockdown in the Netherlands, using data from the Dutch Foundation for Pharmaceutical Statistics (SFK), which covers approximately 96% of all pharmacy dispensations (5.46 million patients). First-time dispensing was defined as no use of hypnotics in the previous year and included benzodiazepines, benzodiazepine-related drugs, and melatonin receptor agonists. Data from 2020 were analysed across three periods: pre-lockdown (Weeks 1-11), lockdown (Weeks 12-19) and post-lockdown (Weeks 20-26), and were compared to the same periods in 2019. Analyses were stratified by age group (children: 0-9, adolescents: 10-19, adults: 20-64, elderly: 65+) and sex. The data revealed a significant reduction in first-time hypnotic dispensations in 2020 (155,961) compared to 2019 (168,814, p < 0.001), with declines across all three time periods (p < 0.001). During the lockdown, significant reductions were found among children, adolescents, and adults (p < 0.001), but not among the elderly. Female adults and the elderly received significantly more hypnotics than their male counterparts (p < 0.001), consistent with higher reported rates of sleep disturbances. In conclusion, the overall number of first-time dispensed hypnotics was significantly lower during the first COVID-19 lockdown in the Netherlands, except among the elderly. It remains unclear to what extent individuals self-medicated with over-the-counter sleep medication, or experienced untreated sleep complaints during the first lockdown in the Netherlands.

Indexed as

COVID-19Hypnotics and SedativesQuarantineAdolescentAdultAgedBenzodiazepinesChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedNetherlandsYoung AdultBenzodiazepinesHypnotics and SedativesCOVID‐19delayed healthcarehypnotic drugslockdownprescriptions

Identifiers

PMID40851454
PMCPMC13003303

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.