ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Blood Biomarkers of Alzheimer Disease and Rates of Global and Domain-Specific Cognitive Decline.JAMA network open · 2026Article
- Considerations in Alzheimer's Disease in Women.Current neurology and neuroscience reports · 2026Review
- Age at menopause,Research square · 2026Article
- Blood pressure polygenic score, cardiorespiratory fitness and odds of dementia: the HUNT Study.Age and ageing · 2026Article
- Sex differences in modifiable risk factors of dementia and their associations with cognition.Biology of sex differences · 2026Article
- A systematic review of the association between phase angle and cognitive function among older adults.GeroScience · 2026Review
- Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Risk prediction for cardiovascular related diseases using PRS and EHR in the Framingham Heart Study.PloS one · 2026Article
- Comorbidity sequence, sex, and APOE-genotype forecast Alzheimer's disease diagnosis.Frontiers in medicine · 2026Article
- From artery to memory: a comparative review of vascular cognitive impairment surgical models.Frontiers in aging neuroscience · 2026Review
- Dementia Prevalence in the CARhES Cohort: Importance of Socioeconomic Level.Journal of clinical medicine · 2025Article
- Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Sex differences in blood pressure hemodynamics and white matter hyperintensity volume across racial ethnic groups-HABS-HD.Alzheimer's & dementia (New York, N. Y.)Article
- Polypharmacy is associated with lower progression from MCI to Alzheimer's disease, with sex-specific patterns across drug classes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Growing evidence underscores the importance of cardiovascular contributions to Alzheimer's disease and related dementias (AD/ADRD). While sex differences in cardiovascular disease (CVD) risk factors and outcomes are well established, the question of whether vascular contributions to AD/ADRD vary by sex has only recently garnered attention. In this narrative review, we discuss sex differences in conventional CVD risk factors (e.g., hypertension, dyslipidemia, diabetes), as well as underrecognized female-specific (e.g., menopause history, polycystic ovary syndrome, adverse pregnancy outcomes) and female-predominant (e.g., autoimmune conditions, breast cancer) CVD risk factors. Despite their relevance, these sex-specific considerations are rarely incorporated into current approaches to quantify CVD risk in AD/ADRD research. We offer recommendations to address these gaps and promote the use of sex-informed methods for studying cardiovascular contributions to AD/ADRD in women, which is essential for developing precision strategies to improve outcomes for all individuals at risk of dementia. HIGHLIGHTS: There are extensive sex differences in cardiovascular risk, dementia risk, and their interrelationships. Many cardiovascular risk factors confer greater risk for dementia in women than men. Existing approaches to quantifying cardiovascular risk often overlook sex differences and female-specific factors. Sex-informed approaches are essential for an accurate understanding of cardiovascular contributions to dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.