Evidence map›Paper›PMID 40851359›Full record

ArticleEuropean journal of immunology2025

Sustained Lung Inflammation Post-SARS-CoV-2 Infection in Mice Is Associated with Increased Pulmonary T Cells.

Sophie Y Guan, Patricia P Ogger, Ana Farias, Minerva Garcia Martín, Joy Nakawesi, Olivia Bedard, Candice Baker, Nadia Rosenthal, Cecilia Johansson

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophie Y GuanRespiratory Infections Section, National Heart and Lung Institute, Imperial College, London, UK.
Patricia P OggerRespiratory Infections Section, National Heart and Lung Institute, Imperial College, London, UK.
Ana FariasRespiratory Infections Section, National Heart and Lung Institute, Imperial College, London, UK.
Minerva Garcia MartínRespiratory Infections Section, National Heart and Lung Institute, Imperial College, London, UK.
Joy NakawesiRespiratory Infections Section, National Heart and Lung Institute, Imperial College, London, UK.
Olivia BedardThe Jackson Laboratory, Bar Harbor, Maine, USA.
Candice BakerThe Jackson Laboratory, Bar Harbor, Maine, USA.
Nadia RosenthalThe Jackson Laboratory, Bar Harbor, Maine, USA.
Cecilia JohanssonRespiratory Infections Section, National Heart and Lung Institute, Imperial College, London, UK.ORCID 0000-0002-6607-5000

Funding

Rosetrees Trust and Stoneygate TrustRosetrees Trust and The John Black Charitable Foundation (M956)UKRI-BBSRC (BB/V013831/1)UKRI-MRC (MR/V000659/1 and MR/X001075/1)
6 · The paper itself

Abstract

Many SARS-CoV-2 patients experience chronic pulmonary symptoms and long-term inflammation despite viral clearance. While these clinical manifestations have been linked to the dysregulation of the adaptive immune response, the underlying immunopathology remains poorly understood due to a lack of suitable animal models. To investigate long-term pulmonary consequences of SARS-CoV-2 infection, we used a genetic cross of 129 mice and C57BL/6 (B6)-K18-hACE2 transgene mice, a model previously shown to survive infection. 129xB6-K18-hACE2 mice or littermate controls were infected with a low dose (5 × 10

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19LungPneumoniaSARS-CoV-2Angiotensin-Converting Enzyme 2AnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, TransgenicAngiotensin-Converting Enzyme 2immune responsesinfectious diseasesinflammationlung inflammationT cells

Identifiers

PMID40851359
PMCPMC12375910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.