Evidence map›Paper›PMID 40851339›Full record

ArticleMagnetic resonance in medicine2025

Mimicking focused ultrasound with a loop coil in acoustic radiation force imaging.

Kristen Zarcone, Anuj Sharma, William A Grissom

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristen ZarconeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0008-8199-9691
Anuj SharmaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0001-2782-1242
William A GrissomDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-3289-1827

Funding

Interdisciplinary Biomedical Imaging Training ProgramT32EB007509 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI DAVID Lynn WILSON, Xin Yu · 2007 to 2026
$5.6M
Translating an MR-guided focused ultrasound system for first-in-human precision neuromodulation of pain circuitsUG3NS135551 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASKEY, CHARLES F, CHEN, LI MIN · 2023 to 2023
$4.4M
Next generation transcranial ultrasound-based neuromodulation using phase shift nanoemulsionsR01MH132022 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Charles F Caskey · 2023 to 2026
$3.3M
Biophysical and Neural Basis of Focused Ultrasound StimulationRF1NS126144 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASKEY, CHARLES F, CHEN, LI MIN · 2022 to 2022
$2.7M
NIBIB NIH HHS T32 EB007509NIH HHS 3T32EB007509NIH HHS R01MH132022NIH HHS RF1NS126144NIH HHS UG3NS135551NIMH NIH HHS R01 MH132022NINDS NIH HHS RF1 NS126144NINDS NIH HHS UG3 NS135551
6 · The paper itself

Abstract

purposeTo enable development of MR-acoustic radiation force imaging (MR-ARFI) methods for targeting ultrasound in human subjects without the regulatory, acoustic, or hardware challenges associated with actual transcranial ultrasound setups.

methodsMR-ARFI is a phase-contrast imaging method that measures focal tissue displacement produced by an ultrasound transducer, when the transducer is pulsed simultaneously with a motion encoding gradient. The ultrasound-induced focal phase shift can be mimicked with a small loop coil that is driven by a DC pulse to produce a resonance frequency offset at the same time as the ultrasound pulse in an MR-ARFI pulse sequence. A coil was designed and built for use in MR-ARFI. Its focus size was characterized, its field map was measured, and volunteer experiments were performed to demonstrate its function in transcranial phase-contrast and magnetization-prepared MR-ARFI.

resultsOff-resonance field maps measured with the constructed loop coil were within 0.87% of simulations in a slice 15 mm from the coil's surface. Its "focus" further had a full-width-at-half-maximum of 22.9 mm in simulation versus 22.7 mm in the field map. In vivo results showed that the same coil driven with 13.7 mA current produced a phase shift corresponding to a realistic effective displacement of 3.5

conclusionA pulsed DC loop coil can mimic ARF-induced displacements in vivo, facilitating development of MR-ARFI methods in vivo.

Indexed as

Elasticity Imaging TechniquesMagnetic Resonance ImagingBrainComputer SimulationEquipment DesignHumansImage Processing, Computer-AssistedPhantoms, ImagingTransducersUltrasonographyfocused‐ultrasoundMR‐ARFI

Identifiers

PMID40851339
PMCPMC12501678

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.