Evidence map›Paper›PMID 40851209›Full record

ArticleAutophagy2025

LC3 and GABARAP independent autophagy of misfolded procollagen in mouse osteoblasts.

Elena Makareeva, Shakib Omari, Anna M Roberts-Pilgrim, Laura Gorrell, Bella Radant, Muthulakshmi Sellamani, Edward L Mertz, Basma Khoury, Kenneth Kozloff, Sergey Leikin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Emerging mechanisms of ATG8-independent non-canonical autophagy.Journal of physiology and biochemistry · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena MakareevaEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Shakib OmariEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Anna M Roberts-PilgrimEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Laura GorrellEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Bella RadantEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Muthulakshmi SellamaniEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Edward L MertzEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Basma KhourySchool of Kinesiology, Department of Orthopaedic Surgery, and Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Kenneth KozloffSchool of Kinesiology, Department of Orthopaedic Surgery, and Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Sergey LeikinEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7095-0739

Funding

Collagen-related diseases ZIAHD000256 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LEIKIN, SERGEY · 2009 to 2025
$19.7M
Intramural NIH HHS ZIA HD000256
6 · The paper itself

Abstract

Bone synthesis should depend on autophagy because over 10% of type I procollagen (PC1) - a heterotrimer of COL1A1 and COL1A2 chains and the precursor of the main bone matrix molecule - is misfolded and rerouted from osteoblast endoplasmic reticulum (ER) to lysosomes. However, osteoblast-specific macroautophagy knockouts in mice have produced only mild bone effects. To reconcile these observations, we compared how hypomorphic expression and a conditional knockout (cKO) of

Indexed as

Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsAutophagyMicrotubule-Associated ProteinsOsteoblastsProcollagenProtein FoldingAnimalsAutophagosomesAutophagy-Related Protein 5Collagen Type IEndoplasmic ReticulumLysosomesMiceMice, KnockoutAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsAtg5 protein, mouseAutophagy-Related Protein 5Collagen Type IGABARAP protein, mouseMap1lc3b protein, mouseMicrotubule-Associated ProteinsProcollagenATG5boneERES microautophagyER exit siteG610C mutationosteogenesis imperfecta

Identifiers

PMID40851209
PMCPMC12487762

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.