ArticleBMC musculoskeletal disorders2025
Exploring the threshold relationship between PTH level and P1NP level in patients with osteoporotic fractures: a retrospective cross-sectional study.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPTH plays a crucial role in bone remodelling by regulating bone formation. Pre-collagen type 1 N-terminal peptide (P1NP) is a key biomarker indicative of new bone formation. However, the relationship between PTH levels and P1NP levels in patients with osteoporotic fractures (OPFs) has not been fully elucidated.
methodsThis study analyzed data from 588 OPFs patients hospitalized between January 2015 and March 2022. Serum P1NP concentration serve as the dependent variable, while PTH level serve as the exposure variable. Covariates included age, gender; Charlson comorbidity index (CCI), body mass index (BMI), lymphocyte, neutrophil, monocyte, low-density lipoprotein (LDL), platelet, triglyceride, albumin, hemoglobin. Generalized estimating equations were used to assess the independent association between PTH and P1NP levels, adjusting for covariates. Non-linear relationships were evaluated using generalized additive models.
resultsThis study found a positive association between PTH level and P1NP level in patients with OPFs (β = 0.59; 95% CI [confident interval] = 0.22 to 0.96; P = 0.0018). This association remained significant after multivariate adjustment. Moreover, the nonlinear model showed a threshold effect, with PTH level below 16.63 (pg/mL) being positively correlated with P1NP (β = 1.69; 95% CI = 0.90 to 2.47; P < 0.0001). However, this correlation did not hold true for PTH level above 16.63 (pg/mL) (β = 0.37; 95% CI = -0.34 to 1.07; P = 0.3091).
conclusionThis study identified an inflection point and a nonlinear, threshold effect in the relationship between PTH and P1NP levels. Further research is needed to confirm these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.