Evidence map›Paper›PMID 40851055›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Longitudinal changes in [

Denise Cerne, Stefano Raffa, Giulia Benvenuto, Giacomo Rebella, Pietro Mattioli, Giacomo Bavestrello, Anastasia Lechiara, Emanuela Maria Mobilia, Dario Arnaldi, Flavio Villani and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Denise CerneDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Stefano RaffaIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giulia BenvenutoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Giacomo RebellaIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Pietro MattioliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Giacomo BavestrelloDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Anastasia LechiaraAutoimmunology Laboratory, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Emanuela Maria MobiliaAutoimmunology Laboratory, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Dario ArnaldiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Flavio VillaniIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Luca RoccatagliataIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giampaola PesceAutoimmunology Laboratory, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Matteo PardiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Silvia MorbelliDepartment of Medical Sciences, University of Turin, Turin, Italy.
Antonio UccelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Luana BenedettiIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Federico MassaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy. fedemassa88@gmail.com.ORCID 0000-0001-5667-204X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecent advancements in autoimmune encephalitis (AE) have enhanced diagnosis and management, but predicting long-term outcomes remains challenging. This study aims to evaluate longitudinal changes in brain [

methodsThis longitudinal study compared brain [

resultsThree VOIs showed significant metabolic changes between baseline (BS) and follow-up (FU) assessments. VOI-A, which was relatively hypermetabolic at BS, included the caudate-thalamus-parahippocampal region, right amygdala, and anterior cingulate cortex. VOI-B1 and VOI-B2, relatively hypometabolic at BS, corresponded to the right fusiform gyrus, precuneus, and temporo-parietal cortex, respectively. Poorer metabolic recovery in all VOIs to normalcy correlated with greater disability (mRS) in both acute and post-therapy phases. Lower metabolism in BS VOI-B1 predicted higher Clinical Assessment Scale in Autoimmune Encephalitis (CASE) score at FU and relapses, while lower age was a significant predictor of escalation to second-line treatment.

conclusionsLongitudinal [

Indexed as

BrainEncephalitisFluorodeoxyglucose F18Hashimoto DiseasePositron-Emission TomographyAdultAgedBiomarkersFemaleHumansLongitudinal StudiesMaleMiddle AgedPrognosisYoung AdultBiomarkersFluorodeoxyglucose F18Autoimmune encephalitisBiomarkersFDG-PETPrognosis

Identifiers

PMID40851055
PMCPMC12830435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.