Evidence map›Paper›PMID 40851006›Full record

ArticlePneumonia (Nathan Qld.)2025

Clinical features and prognosis of severe legionnaires' disease requiring intensive care unit admission: a multicentric retrospective cohort study.

Anaïs Dartevel, Louis-Marie Galerneau, Vincent Peigne, Nicholas Sedillot, Stephan Ehrmann, Alexandre Lautrette, Kada Klouche, Julien Poissy, Guillaume Thiery, Bertrand Sauneuf and 5 more

Abstract read
In one paragraph

Article in Pneumonia (Nathan Qld.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anaïs DartevelMedical Intensive Care Unit, University Hospital of Grenoble Alpes, Grenoble, CS, France.
Louis-Marie GalerneauMedical Intensive Care Unit, University Hospital of Grenoble Alpes, Grenoble, CS, France.
Vincent PeigneIntensive Care Unit, Centre Hospitalier Métropole-Savoie, Chambéry, France.
Nicholas SedillotIntensive Care Unit, Centre Hospitalier, Bourg en Bresse, France.
Stephan EhrmannMédecine Intensive réanimation, Médecine Intensive Réanimation, Centre Hospitalier Universitaire Tours and Centre d'étude des pathologies respiratoires, CIC INSERM 1415, CRICS-TriggerSEP F-CRIN research network, INSERM U1100, Tours University, Tours, France.
Alexandre LautretteMedical Intensive Care Unit, Centre Hospitalier Universitaire, Clermont- Ferrand, France.
Kada KloucheMedical Intensive Care Unit, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
Julien PoissyMedical Intensive Care Unit, Centre Hospitalier Universitaire Lille, Lille, France.
Guillaume ThieryMedical Intensive Care Unit, Centre Hospitalier Universitaire Saint- Etienne, Saint-Étienne, France.
Bertrand SauneufIntensive Care Unit, Centre Hospitalier Public du Cotentin, Cherbourg-en- Cotentin, France.
Jean-Philippe RigaudIntensive Care Unit, Centre Hospitalier Dieppe, Dieppe, France.
Michel RamakersIntensive Care Unit, Centre Hospitalier Saint-Lô, Saint-Lô, France.
Cédric DaubinMedical Intensive Care Unit, Centre Hospitalier universitaire de Caen, de Caen, France.
Carole SchwebelMedical Intensive Care Unit, University Hospital of Grenoble Alpes, Grenoble, CS, France.
Nicolas TerziMedical Intensive Care Unit, Centre Hospitalier universitaire de Rennes, de Rennes, France. nicolas.terzi@chu-rennes.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLegionella is the second cause of community-acquired pneumonia in Intensive Care Unit (ICU) patients. The aim of this study was to describe the epidemiology and outcome in patients with Legionella pneumonia (LP) in French ICUs.

methodsA multi-center, retrospective, observational study in 12 French ICUs was performed between January 2014 and December 2019.

resultsLP was diagnosed in 162 patients during the study period. Invasive mechanical ventilation was required in 95 patients (58%), 73 (45%) of whom had acute respiratory distress syndrome (ARDS). Most of these patients were treated with a combination of antibiotics (128, patients; 79%). The most common combination consisted in a fluoroquinolone and a macrolide (118 patients). Median length of stay in an ICU was 11 [5; 11] days. At 28 days, 19 (12%) out of the 162 patients had not survived. In multivariate analyses, age (Incidence risk Ratio: IRR, 1.07; 95% CI, 1.01; 1.14) and a high Sequential Organ Failure Assessment (SOFA) score in the first 48 h (IRR, 1.47; 95% CI, 1.09; 2) were significantly associated with mortality.

conclusionIn this French multicentric cohort, the LP prognosis in ICUs was apparently more favorable than in the literature, possibly because of the timely and improved LP management in ICUs.

Indexed as

AntibiotherapyIntensive Care UnitLegionella pneumophilaSeptic shock

Identifiers

PMID40851006
PMCPMC12376721

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.