Evidence map›Paper›PMID 40850934›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease.

V Alexandra Moser, Luz Jovita Dimas-Harms, Rachel M Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J Parker and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. "Time Is Brain" - for Cell Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

V Alexandra MoserBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.ORCID https://orcid.org/0000-0001-7365-0176
Luz Jovita Dimas-HarmsBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Rachel M LipmanBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Jake InzalacoBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Shaughn BellBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Michelle AlcantaraBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Erikha ValenzuelaBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
George LawlessBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Simion KreimerSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
Sarah J ParkerSmidt Heart Institute, Department of Cardiology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
Helen S GoodridgeBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.
Clive N SvendsenBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, Los Angeles, CA, 900048, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Young blood or plasma improves cognitive function in aged animals but has limited availability. The current study generates a subtype of young blood cells from easily expandable induced pluripotent stem cells and evaluates their effects on age- and Alzheimer's disease (AD)-associated cognitive and neural decline. In aging mice, intravenous delivery of induced mononuclear phagocytes (iMPs) improves performance in hippocampus-dependent cognitive tasks, increases neural health, and reduces neuroinflammation. Hippocampal single nucleus RNA-sequencing shows that iMPs improve the health of a subpopulation of mossy cells that are critically involved in the type of cognitive task in which iMPs improve performance, and shows that iMPs decrease the transcriptional age of several hippocampal cell types. Plasma proteomic analyses reveal that iMPs can also reverse age-associated increases in serum amyloid levels. This is verified in vitro, where iMP-conditioned media is shown to protect human microglia against cell death induced by serum amyloids. Finally, iMPs improve cognition in both young and aging 5×FAD mice, highlighting their potential as a prevention as well as an intervention strategy. Together, these findings suggest that iMPs provide a novel therapeutic strategy to target both age- and AD-related cognitive decline.

Indexed as

AgingAlzheimer DiseaseCognitionInduced Pluripotent Stem CellsPhagocytesAnimalsDisease Models, AnimalHippocampusHumansMaleMiceagingAlzheimer's diseasemononuclear phagocytesneural healthserum amyloids

Identifiers

PMID40850934
PMCPMC12591165

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.