Evidence map›Paper›PMID 40850749›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

Inter-rater reliability of atherosclerotic plaque enhancement on 7 T vessel wall MRI: Comparison with quantitative analysis.

Carlos Dier, Sultan Alhajahjeh, Abdallah A Alqudah, Andres Gudino, Navami Shenoy, Martin A Cabarique, Elena Sagues, Sebastian Sanchez, Connor Aamot, Linder Wendt and 3 more

Abstract read
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carlos DierDepartment of Neurology, University of Iowa, Iowa City, IA, USA.ORCID 0009-0009-8243-9087
Sultan AlhajahjehDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Abdallah A AlqudahDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Andres GudinoDepartment of Neurology, University of Iowa, Iowa City, IA, USA.ORCID 0009-0003-0123-6138
Navami ShenoyDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Martin A CabariqueDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Elena SaguesDepartment of Neurology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-8192-1906
Sebastian SanchezDepartment of Neurology, Yale University, New Haven, CT, USA.
Connor AamotDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Linder WendtInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA, USA.
Bruno A PoliceniDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Minako HayakawaDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
Edgar A SamaniegoDepartment of Neurology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-2764-2268

Funding

University of Iowam - Whole Body 7T MRI ScannerS10RR028821 · NCRR · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2010 to 2010
$8.0M
NCRR NIH HHS S10 RR028821
6 · The paper itself

Abstract

ObjectiveIntracranial plaque enhancement (IPE) is a potential biomarker of plaque vulnerability but lacks a standardized definition. While subjective assessment may be prone to observer variability, a voxel-based quantification method can detect subtle signal intensity (SI) changes. This study aimed to compare the inter-rater reliability of subjective IPE evaluation with that of a voxel-based quantification method.MethodsPatients with stroke due to intracranial atherosclerosis were prospectively imaged using 7 T vessel wall magnetic resonance imaging. Two adjudicators independently assessed IPE, with discrepancies resolved by a third, experienced neuroradiologist. IPE distribution was quantified using a semiautomated method based on SI measurements from post-contrast T1-weighted images. The mean enhancement ratio was calculated for each plaque to assess gadolinium enhancement. Inter-rater reproducibility and the concordance between subjective and objective assessments were evaluated. Regression analysis was performed to identify plaque morphological features that influenced the reliability of subjective IPE adjudication compared to the objective method.ResultsWe analyzed 75 plaques from 41 patients. Inter-rater agreement for IPE adjudication was poor (

Indexed as

gadoliniumhigh-resolution vessel wall imagingIntracranial plaque enhancementmean enhancement ratiosignal intensity

Identifiers

PMID40850749
PMCPMC12375601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.