Evidence map›Paper›PMID 40850617›Full record

ArticleKidney international2025

Low prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection.

Peter P Reese, Sumit Mohan, Douglas E Schaubel, Rachel Forbes, Shikha Mehta, E Steve Woodle, Nianfu Song, Meghan E Sise, Raymond T Chung, Christine M Durand and 15 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Peter P ReeseVanderbilt Center for Transplant Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address: peter.reese@vumc.org.
Sumit MohanDepartment of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Douglas E SchaubelDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rachel ForbesDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shikha MehtaDepartment of Medicine, Division of Nephrology, University of Alabama, Birmingham, Alabama, USA.
E Steve WoodleDepartment of Surgery, University of Cincinnati, Cincinnati, Ohio, USA.
Nianfu SongDepartment of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Meghan E SiseDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Raymond T ChungDepartment of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christine M DurandDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Niraj DesaiDepartment of Surgery, Northwell Transplant Institute, Manhasset, New York, USA.
Elizabeth C VernaDepartment of Medicine, Division of Digestive and Liver Disease, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.
Therese BittermannDepartment of Medicine, Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maria BlancoCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David ShafferDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Beatrice P ConcepcionDepartment of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois, USA.
Rita R AllowayDepartment of Surgery, University of Cincinnati, Cincinnati, Ohio, USA.
Javier A PaganDepartment of Medicine, Katz Family Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida, USA.
Derek A DuBayDepartment of Surgery, Prisma Health University Medical Group, Greenville, South Carolina, USA.
John W McGillicuddyDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Vishnu PotluriDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anne M HumlDepartment of Kidney Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Dominick SantorielloDepartment of Pathology, Renal Pathology Laboratory, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.
M Barry StokesDepartment of Pathology, Renal Pathology Laboratory, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.
David S GoldbergDepartment of Medicine, Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1M
A trial of transplanting Hepatitis C-viremic kidneys into Hepatitis C-Negative kidney recipients (THINKER-NEXT)U01DK126654 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GOLDBERG, DAVID SETH, REESE, PETER PHILIP · 2021 to 2025
$7.8M
NCI NIH HHS P30 CA240139NIDDK NIH HHS U01 DK126654
6 · The paper itself

Abstract

introductionHepatitis C virus (HCV) infection is a leading cause of immune-complex mediated glomerulonephritis, specifically cryoglobulinemic and membranoproliferative glomerulonephritis, and has also been associated with non-glomerular kidney diseases. However, the prevalence of kidney disease among individuals with chronic HCV infection is unknown. Concerns about the quality of kidneys from deceased donors with HCV infection may lead centers to avoid transplanting these organs.

methodsWe assembled a multicenter histological database of deceased donor biopsies to compare the prevalence of glomerulonephritis and chronic disease pathology among 147 transplanted kidneys from HCV-RNA

resultsThe mean age was 40.3 versus 40.7 years for HCV-RNA

Indexed as

GlomerulonephritisHepatitis CHepatitis C, ChronicKidneyKidney TransplantationTissue DonorsAdultBiopsyFemaleHepacivirusHumansMaleMiddle AgedPrevalenceRetrospective StudiesRNA, ViralRNA, Viralglomerulonephritishepatitis C virushistologykidney transplantation

Identifiers

PMID40850617
PMCPMC12380177

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.