ArticleBrain, behavior, and immunity2025
Discrimination and dendritic cell abundance among older adults in the health and retirement study.
Article in Brain, behavior, and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Discrimination exposure and lymphocyte differentiation: Results from the health and retirement study.Brain, behavior, & immunity - health · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
We investigated whether peripheral blood dendritic cell (DC) abundance varies as a function of discrimination exposure in a national sample of older US adults (aged 50 + years) from the 2016 Venous Blood Study, a US Health and Retirement Study biomarker project. Density of myeloid DCs (mDC) and plasmacytoid DCs (pDC) were measured using multiparameter flow cytometry. Discrimination was assessed using the validated Everyday Discrimination Scale. Weighted linear regression models quantified associations between discrimination and natural-log transformed DC abundance, controlling for sociodemographic factors, chronic health conditions, and health behaviors. We tested whether these associations varied by race/ethnicity. For mDC, we found no significant overall association with discrimination. However, race/ethnicity significantly modified this relationship: among non-Hispanic White participants, a 1-SD increase in discrimination was associated with a non-significant 1.4 % increase in mDC count (p = 0.20), while non-Hispanic Black participants showed a significant 4.6 % decrease (interaction p = 0.021). For pDC, a 1-SD change in discrimination was significantly associated with a 2.4 % increase in abundance across all participants (95 % CI: 0.6 %, 4.3 %, p = 0.010), with no significant effect modification by race/ethnicity. In this nationally representative study of older Americans, discrimination exposure was associated with altered dendritic cell abundance, with distinct patterns by cell type and race/ethnicity. Increased pDC counts across all racial/ethnic groups suggest a common immunological response to discrimination, while divergent mDC responses between non-Hispanic Black and White participants indicate race-specific immune modulation. These findings reveal complex cellular pathways through which discrimination may differentially influence immune function and contribute to health inequities.
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Registered trials
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