Evidence map›Paper›PMID 40849968›Full record

Observational studyEuropean journal of oncology nursing : the official journal of European Oncology Nursing Society2025

Biobehavioral correlates of multidimensional fatigue in men with prostate cancer: A secondary data analysis.

Kristin Dickinson, Kevin Kupzyk, Christopher Wichman, Andrew Lim, Lani Zimmerman, Anna L Schwartz, Bunny Pozehl

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of oncology nursing : the official journal of European Oncology Nursing Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristin DickinsonCollege of Nursing, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: kad448@pitt.edu.
Kevin KupzykCollege of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
Christopher WichmanCollege of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Andrew LimCollege of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
Lani ZimmermanCollege of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
Anna L SchwartzColeman Health, LLC, Parks, AZ, USA.
Bunny PozehlCollege of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

Cancer-Related Fatigue and the Adaptive Response to Oxidative StressR00NR015822 · NINR · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DICKINSON, KRISTIN ASHLEY · 2018 to 2020
$746k
NINR NIH HHS R00 NR015822
6 · The paper itself

Abstract

purposeThe purpose of this secondary analysis was to 1) examine trajectories of multidimensional cancer-related fatigue (CRF) in men with prostate cancer during and after radiation treatment completion, and 2) identify biobehavioral correlates (demographic, clinical, co-occurring symptoms, and biologic [inflammatory cytokines]) for the different CRF dimensions.

methodsData were obtained from a descriptive, longitudinal IRB-approved study investigating the biology of CRF in men with prostate cancer receiving radiation therapy. Data were included from 68 participant medical records, self-report questionnaires, and blood samples. Multidimensional CRF was assessed using the MFSI-SF questionnaire. Data were collected at: baseline (T1), completion of radiation therapy (T2), 6 months (T3) and 24 months (T4) after completion of radiation therapy. Spearman Rank correlations between MFSI-SF subscale scores and patient reported outcomes and biomarker values were computed for each time point.

resultsMost dimensions (general, physical, mental) of CRF worsened during treatment, with the exception of improved emotional fatigue. After treatment completion, most CRF dimensions (general, physical, mental) improved, while emotional fatigue remained steady. During treatment, co-occurring symptoms (anxiety, depression, pain, difficulty sleeping) were each observed to be associated with different CRF dimensions. After treatment completion, prostate cancer risk group, co-occurring symptoms, and IL-8 were observed to be associated with different CRF dimensions.

conclusionThe findings support that there may be unique correlates, including biologic correlates, for the different dimensions of CRF. Understanding the different dimensions of CRF is critical for development of tailored assessments and interventions targeted to the unique CRF dimensions to optimize management.

Indexed as

FatigueProstatic NeoplasmsAdultAgedBiomarkers, TumorHumansInterleukin-8Longitudinal StudiesMaleMiddle AgedSecondary Data AnalysisStatistics, NonparametricSurveys and QuestionnairesBiomarkers, TumorCXCL8 protein, humanInterleukin-8Cancer-related fatigueMultidimensionalProstate cancerRadiation

Identifiers

PMID40849968
PMCPMC12981357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.