Evidence map›Paper›PMID 40849812›Full record

ArticleMolecular medicine reports2025

Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia.

Peng Wang, Mengxia Li, Wenxuan Wang, Weiguo Sun, Wen Zhen, Qian Sun, Bo Ning, Guanghao Su, Xiaodong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng WangDepartment of Pediatric Surgery, Jiaxing Women and Children's Hospital Affiliated with Wenzhou Medical University, Jiaxing, Zhejiang 314000, P.R. China.
Mengxia LiPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.
Wenxuan WangPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.
Weiguo SunPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.
Wen ZhenPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.
Qian SunPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.
Bo NingDepartment of Pediatric Orthopedics, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai 201100, P.R. China.
Guanghao SuPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.
Xiaodong WangPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, Jiangsu 215024, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Residual acetabular dysplasia (RAD) is a common complication after the successful management of developmental dysplasia of the hip (DDH). RAD remodeling is important for predicting the outcome of the affected hip, and optimal treatment can be chosen accordingly. Regenerating islet‑derived protein 3‑β (Reg3β), a multifaceted cytokine, is a prognostic marker for inflammation and cardiac disease. Nevertheless, the roles of Reg3β in RAD remain unclear. Consequently, the aim of the present study was to assess the role of Reg3β in RAD and explore its related functions in chondrocytes

Indexed as

AcetabulumChondrocytesDevelopmental Dysplasia of the HipExtracellular MatrixPancreatitis-Associated ProteinsAnimalsCell ProliferationDisease Models, AnimalJanus Kinase 2MaleRatsRats, Sprague-DawleySignal TransductionSTAT3 Transcription FactorJanus Kinase 2Pancreatitis-Associated ProteinsSTAT3 Transcription Factoranti‑apoptosischondrocytesextracellular matrix metabolismproliferationregenerating islet‑derived protein 3βresidual dysplasia of the hip

Identifiers

PMID40849812
PMCPMC12382431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.