ArticleMolecular pharmaceutics2025
PROTAC Enabling Formulation
Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- From prediction to performance:International journal of pharmaceutics: X · 2026Article
- Unlocking the potential of alkaline polymethacrylates via ionic crosslinking in amorphous solid dispersions.International journal of pharmaceutics: X · 2026Article
- High Bioavailability Resveratrol Delivery System: A Novel Nutritional Strategy for the Prevention and Alleviation of Rheumatoid Arthritis.Food science & nutrition · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteolysis targeting chimeras (PROTACs) are heterobifunctional degraders with a unique mode of action that permits access to "undruggable" targets. These molecules pose challenges in terms of solubility and bioavailability due to their physicochemical properties. So far, very little information is available on the potential of enabling formulations of PROTACs in pharmacokinetic studies. In a previous work of our group, amorphous spray-dried formulations (SDDs) of the model PROTAC MS4078 were developed. However, the potential of the amorphous solid dispersions of the PROTAC MS4078 has not yet been examined
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.