Evidence map›Paper›PMID 40849788›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Lipid with Lewis Pair-Mediated Targeting and Multiple Stimuli-Responsive Delivery of Antibiotics for Bacterial Infections.

Xiaojian Yan, Lei Hua, Hongping Wan, Yong Liu, Tao Jin, Yicen Ge, Michael R Hamblin, Mahdi Karimi, Xinghong Zhao, Yan Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojian YanZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gynecology, Consortium for Infection and Innovation (CII), First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.
Lei HuaZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gynecology, Consortium for Infection and Innovation (CII), First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.
Hongping WanCenter for Sustainable Antimicrobials, Center for Infectious Diseases Control (CIDC), Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Yong LiuZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gynecology, Consortium for Infection and Innovation (CII), First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.ORCID https://orcid.org/0000-0003-1738-7857
Tao JinCollege of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu, Sichuan, 610059, China.
Yicen GeCollege of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu, Sichuan, 610059, China.
Michael R HamblinLaser Research Centre, University of Johannesburg, Doornfontein, Johannesburg, 2028, South Africa.
Mahdi KarimiCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 14535, Iran.
Xinghong ZhaoCenter for Sustainable Antimicrobials, Center for Infectious Diseases Control (CIDC), Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Yan HuZhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gynecology, Consortium for Infection and Innovation (CII), First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.
Linqi ShiTranslational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325001, China.
Yuanfeng LiTranslational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325001, China.

Funding

National Natural Science Foundation of China 22275043National Natural Science Foundation of China 22475156National Natural Science Foundation of China 52203184National Natural Science Foundation of China 52293383National Natural Science Foundation of China 52422307
6 · The paper itself

Abstract

Integrating both targeted delivery and stimulus-responsive release into a single small molecule for drug delivery presents challenges related to synthesis, stability, and efficacy. In this study, single-molecular lipids incorporating a Lewis pair (Lp-lipids) are described, composed of a Lewis acid (phenylboronic acid) and a Lewis base (amine) within a single small molecular structure, to formulate lipid nanoparticles for antibiotic delivery. For targeted delivery to bacterial biofilms, the phenylboronic acid selectively binds to bacteria or biofilms by forming boronate ester bonds with diols in the microbial dextran or peptidoglycan. Additionally, the amine group responds to the acidic microenvironment, enhancing electrostatic interactions with bacteria and biofilms. Regarding stimulus-responsive drug release, the Lewis base reacts to low pH, while the Lewis acid responds to H

Indexed as

Anti-Bacterial AgentsBacterial InfectionsDrug Delivery SystemsLipidsAnimalsBiofilmsBoronic AcidsMiceNanoparticlesAnti-Bacterial AgentsBoronic AcidsLipidsbacterial biofilmsdrug deliverydynamic covalent bondinglipid nanoparticlesmultiple responsiveness

Identifiers

PMID40849788
PMCPMC12631898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.