ReviewCurrent topics in medicinal chemistry2026
Comprehension of the Function of Antioxidants in Targeting Different Signaling Pathways to Cure Oxidative Stress-induced Hepatotoxicity.
Review in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review).Molecular medicine reports · 2026Review
- Multi-omics analysis reveals the mechanism of enhanced GABA production in Lactiplantibacillus plantarum JY7 under acoustic and thermal coupling.Ultrasonics sonochemistry · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Oxidative stress plays a central role in the pathogenesis of liver diseases, including hepatotoxicity, by disrupting the balance between reactive oxygen species (ROS) and the hepatic antioxidant defense system. Excessive ROS production leads to inflammation, fibrosis, and cellular damage. Antioxidants-both endogenous and exogenous-can mitigate these effects by neutralizing ROS and restoring redox homeostasis. This review evaluates the mechanistic role of antioxidants in modulating key oxidative stress-related signaling pathways, such as nuclear factor erythroid 2-related factor 2 (Nrf2), mitogen-activated protein kinases (MAPKs), nuclear factorkappa B (NF-κB), phosphoinositide 3-kinase/Akt (PI3K/Akt), and Janus kinase/signal transducer and activator of transcription (JAK/STAT). Through the regulation of these pathways, antioxidants reduce apoptosis, suppress pro-inflammatory signaling, and enhance the expression of detoxifying enzymes. Natural compounds like flavonoids, polyphenols, and vitamins C and E have shown hepatoprotective effects, while synthetic antioxidants and their combinations with other therapeutic agents represent promising strategies for clinical application. This review underscores the therapeutic potential of antioxidants in combating oxidative stress-induced hepatotoxicity by offering a comprehensive overview of their mechanistic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.