Evidence map›Paper›PMID 40849701›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Association of Interleukin-27 (IL-27) rs181206 T/C and rs17855750 T/G Gene Polymorphisms and the Risk of Hepatitis B Infection among Egyptians.

Abd El-Gaffar Sabry Oluyemi, Noha E Ibrahim, Mohamed M S Farag, Adel Abd El Basset Mousa, Menha Swellam

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abd El-Gaffar Sabry OluyemiDepartment of Microbiology, Faculty of Science, University of Al Azhar, Cairo, Egypt.
Noha E IbrahimDepartment of Microbial Biotechnology, Biotechnology Research Institute, National Research Centre, 33 El-Bohouth St. (former El-Tahrir St.), Dokki, Giza, P.O.12622, Egypt.ORCID 0000-0002-7176-4687
Mohamed M S FaragDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Adel Abd El Basset MousaDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Menha SwellamDepartment of Biochemistry, Biotechnology Research Institute, 5High Throughput Molecular and Genetic Laboratory, Central Laboratories Network, and the Centers of Excellence, National Research Centre, Dokki, Giza, Egypt.ORCID 0000-0002-7104-7194

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveHBsAg incidence in Egypt is at a range of 2 to 7%. Antiviral immunity is linked to interleukin-27 (IL27), a cytokine that is produced by two genes: EBI3 and p28. IL-27 gene SNPs can alter the susceptibility to infection of HVB by impacting the production and/or function of cytokines. The study aimed to examine the impact of the IL-27 SNPs on the progression of HBV infection among Egyptian individuals. MATERIALS AND

methodsThis study included a total 112 patients infected with HBV, and 50 healthy individuals served as controls. The link between the IL-27 SNPs (rs181206 T/C and rs17855750 T/G) and HBV was investigated using real-time PCR.

resultsThere was no significant correlation between fibrosis stages and the distribution of IL-27 rs181206 T/C and rs17855750 T/G genotypes among HBV patients. Results indicated minimal disparity in the distribution of haplotypes among the study groups. No significant difference in the frequency of the CG, CT, TT, TG, and haplotypes between the groups.

conclusionThis study found no correlation between the presence of IL-27 rs1812006 and IL-27 rs17855750 SNPs and the HBV chronicity.

Indexed as

Genetic Predisposition to DiseaseHepatitis BHepatitis B, ChronicHepatitis B virusInterleukin-27InterleukinsPolymorphism, Single NucleotideAdultCase-Control StudiesEgyptFemaleFollow-Up StudiesGenotypeHaplotypesHumansMaleInterleukin-27InterleukinsMYDGF protein, human17855750 T/GHaplotypeHBVIL-27 181206 T/CKeywords: SNP

Identifiers

PMID40849701
PMCPMC12659880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.