ArticleAsian Pacific journal of cancer prevention : APJCP2025
The Ideal Second-Line Treatment Options for Patients with Advanced Biliary Tract Cancer Refractory to Gemcitabine-Based First-Line Chemotherapy: A Result From Bayesian Network-Meta Analysis.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the most ideal second-line treatment for advanced biliary tract cancer, considering the response rate, survival, and drug adverse events.
methodsThis network meta analysis (NMA) was conducted in accordance with the PRISMA with NMA extension guidance. After formulation of PICO, comprehensive searches of literatures were done including all randomized controlled studies that reported the second-line treatment for advanced biliary tract cancers' subjects who have failed with first-line gemcitabine-based chemotherapy. The outcomes analyzed were response rate, progression-free survival, overall survival, and serious adverse events. Data were collected and analysis will be done based on Bayesian method using BUGSnet package in R studio.
resultsEleven eligible RCTs were included in this NMA with 1228 subjects and 15 different second-line therapies. The NMA was conducted in random-effects, consistent, and convergence model. Most studies reported the use of fluoropyrimidine-based regimen, either alone or in combination with others drugs. The combination of 5FU-LV with liposomal irinotecan showed the most favorable outcomes, the highest response rate, longest overall survival, and longest progression-free survival. However, this regimen had highest adverse events among others. The next promising regimen was combination of oral capecitabine with varlitinib, with favorable response rate (RR 16.67; 95%CI 0.01 to 21.39), overall survival (HR 0.09; 95%CI -5.22 to 5.37), and progression-free survival (HR 1.37; 95%CI -58.4 to 62.15). The serious adverse events were reported less than others.
conclusionThe combination of oral capecitabine with varlitinib could be a promising second-line treatment for patients with advanced biliary tract cancer refractory to gemcitabine-based first-line regimen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.