ReviewAsian Pacific journal of cancer prevention : APJCP2025
The Functional Interplay among GAD2, GABRG2, and CACNA1G Genes in Cancers.
Review in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications.Journal of Cancer · 2026Review
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Authors and funding
7 authors.
Funding
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Abstract
The GABAergic system, commonly known as the inhibitory system in the central nervous system, also plays a crucial role in cancer development.
objectiveThis article reviews the complex interactions between the GABAergic system and tumor progression, emphasizing the GAD2, GABRG2, and CACNA1G genes.
methodA comprehensive literature review was conducted to assess current evidence regarding the involvement of GAD2, GABRG2, and CACNA1G genes in promoting cancer development through enhanced tumor growth, cell survival, and increased intracellular calcium levels.
resultWhile GABA generally suppresses neural activity, it can paradoxically promote cell proliferation and survival in cancer cells. The GAD2 gene produces an enzyme that helps create GABA. Higher levels of GAD2 expression have been linked to tumor growth and survival in several types of cancer. The GABRG2 gene encodes a subunit of the GABA-A receptor. When this receptor is activated, it can cause depolarization and activate signaling pathways that promote cancer cell growth. The CACNA1G gene encodes a subunit of a calcium channel that controls calcium ion entry into cells. Higher levels of CACNA1G expression are frequently found in various cancers, contributing to tumor development by increasing intracellular calcium levels.
conclusionThis article examines the role of GAD2, GABRG2, and CACNA1G genes in cancer progression, highlighting their interactions in promoting tumor growth and survival. A deeper understanding of the molecular mechanisms underlying GABA signaling, its receptors, and the associated genes in cancer could lead to the identification of new therapeutic targets and the development of more effective treatments. Further research is essential to elucidate the detailed mechanisms driving cancer development and progression.
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