ArticleAsian Pacific journal of cancer prevention : APJCP2025
Revolutionizing HER2-Positive Breast Cancer Treatment: Insights from the 47th San Antonio Breast Cancer Symposium on Trastuzumab Deruxtecan.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Precision Medicine and Artificial Intelligence in Next-Generation Cancer Surgery: A Comprehensive Analysis of Clinical Applications, Therapeutic Outcomes, and Implementation Strategies.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This editorial discusses the groundbreaking advancements in the treatment of HER2-positive breast cancer presented at the 47th San Antonio Breast Cancer Symposium, focusing on trastuzumab deruxtecan (T-DXd). T-DXd, an innovative antibody-drug conjugate, has shown significant improvements in progression-free survival (PFS) and overall survival (OS) compared to traditional chemotherapy, particularly in patients with HER2-positive metastatic breast cancer. Key studies, including DESTINY-Breast03 and DESTINY-Breast04, demonstrate T-DXd's efficacy and safety across diverse populations, including those with HER2-low tumors and brain metastases. The editorial also highlights the importance of real-world applications, ongoing research into biomarkers, and the potential of combination therapies, such as T-DXd with pyrotinib. The findings suggest that T-DXd not only extends survival but also enhances health-related quality of life for patients, promising a transformative shift in treatment paradigms for HER2-positive breast cancer.
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