Evidence map›Paper›PMID 40849647›Full record

ArticleBMC women's health2025

Environmental heavy metal exposure and altering anti-Mullerian hormone levels in women.

Zahra Namvar, Anoushiravan Mohseni-Bandpei, Abbas Shahsavani, Akbar Eslami, Maryam Mousavi, Fatemeh Shokri Dariyan, Philip K Hopke, Fereidoun Azizi, Fahimeh Ramezani Tehrani

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In one paragraph

Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zahra NamvarAir Quality and Climate Change Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Anoushiravan Mohseni-BandpeiAir Quality and Climate Change Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abbas ShahsavaniAir Quality and Climate Change Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Akbar EslamiDepartment of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam MousaviReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh Shokri DariyanDepartment of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Philip K HopkeDepartment of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Fereidoun AziziEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fahimeh Ramezani TehraniReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. fah.tehrani@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum levels of anti-Mullerian hormone (AMH), a key indicator of ovarian aging, decrease with age. This decline may be accelerated by genetic and environmental factors. Accordingly, the present study investigates the relationship between serum AMH concentrations and exposure to heavy metals.

methodsThis cohort study was conducted on 220 women with a median age of 42 years (Range: 37-45). Participants were reproductive-age women from the Tehran Lipid and Glucose Study (TLGS) that met our inclusion criteria. Serum concentration of heavy metals - including lead (Pb), cadmium (Cd), copper (Cu), aluminum (Al) and chromium (Cr) - as well as AMH levels, were measured using stored samples from the second and fifth follow-up visits with a time interval of approximately 10 years. A multivariate linear regression model was used to assess the relationship between AMH and heavy metals, adjusting for age, body mass index (BMI), smoking, physical activity, age at menarche, education, marital status and parity.

resultsThe results indicated that serum AMH concentration in women classified within the fourth and third quartiles of Cu was reduced by -0.43 (95%CI: -0.73, -0.13) ng/ml and - 0.34 (95%CI: -0.65, -0.03) ng/ml, respectively. No statistically significant associations were observed between AMH levels and other heavy metals, including Pb, Al, and Cr (P > 0.05).

conclusionThese findings suggest a possible link between elevated Cu levels and diminished AMH concentrations in reproductive-age women. However, further research is needed to confirm these findings and to elucidate the underlying factors, particularly in younger age groups.

Indexed as

Anti-Mullerian HormoneEnvironmental ExposureMetals, HeavyAdultAluminumCadmiumChromiumCohort StudiesCopperFemaleHumansIranLeadMiddle AgedAluminumAnti-Mullerian HormoneCadmiumChromiumCopperLeadMetals, HeavyAluminumAnti-mullerian hormoneChromiumCopperLead

Identifiers

PMID40849647
PMCPMC12374403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.