ArticleBMC surgery2025
Postoperative C-reactive protein to albumin ratio as early predictive factors for prolonged postoperative hospital stay after highly advanced hepatobiliary-pancreatic surgery: a single-center retrospective study.
Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative length of hospital stay (PLOS) is an important indicator of surgical quality. Prolonged PLOS (PPLOS) escalates treatment costs and delays the transition from surgery to adjuvant chemotherapy. Additionally, PPLOS can negatively affect long-term prognosis. The predictive factors for PPLOS, particularly following highly advanced hepatobiliary-pancreatic surgery (HBPS), remains insufficiently studied. In this study, we defined PPLOS as a PLOS exceeding the 75th percentile of the cohort and aimed to identify perioperative predictors of PPLOS following highly advanced HBPS.
methodsThis single-center retrospective study included 737 patients who underwent highly advanced HBPS at Gifu University Hospital, Japan, between January 2010 and December 2023. Perioperative predictive factors associated with PPLOS were analyzed in patients with severe postoperative complications within 30 days of surgery (n = 181; Clavien-Dindo classification grades III or IV) using univariate and multivariate analyses.
resultsAmong the included patients, 45 experienced PPLOS, with the 75th percentile of PLOS being 53 days. Univariate analysis identified intra-abdominal abscess, pancreatic fistula, postoperative bleeding, hepatic failure, unplanned intubation, C-reactive protein to albumin ratio (CAR) on postoperative day (POD)3, and neutrophil to lymphocyte ratio (NLR) on POD3 as significantly correlated with PPLOS. Multivariate analysis revealed that CAR on POD3 > 5.0 was the only independent predictor for PPLOS (odds ratio, 3.22; 95% confidence interval, 1.11-10.17; p = 0.03).
conclusionsPLOS was significantly prolonged in patients undergoing highly advanced HBPS who developed severe postoperative complications, regardless of surgery type (hepatobiliary or pancreatic). Among these patients, an elevated CAR on POD3 emerged as an early independent predictor of PPLOS. These findings highlight the significance of early postoperative monitoring and intervention based on CAR to reduce the risk of PPLOS following highly advanced HBPS and thus, minimize severity of postoperative complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.