Evidence map›Paper›PMID 40849606›Full record

ArticleOphthalmology and therapy2025

Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery: A Prospective Double-Masked Randomized Controlled Clinical Trial.

Mihaela-Madalina Timofte-Zorila, Filippo Lixi, Nicoleta Vlas, Mario Troisi, Gamze Özkan, Mariana Pavel-Tanasa, Sinziana Istrate, Cristina Preda, Giulia Coco, Assem Namazbayeva and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07067294 (Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07067294 nacompletednot on this map

Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorGrigore T. Popa University of Medicine and PharmacyRan2025 to 2025Enrolled98ConditionsDry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface DiseaseArmsLow-Level Light Therapy, Sham (No Treatment)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mihaela-Madalina Timofte-ZorilaFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Filippo LixiEye Clinic, Department of Surgical Sciences, University of Cagliari, Via Università 40, 09124, Cagliari, Italy.
Nicoleta VlasFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Mario TroisiEye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, 80131, Naples, Italy.
Gamze ÖzkanBitlis State Hospital, Bitlis, Turkey.
Mariana Pavel-TanasaDepartment of Immunology, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Sinziana IstrateBINE Ophthalmology Clinic, 020483, Bucharest, Romania.
Cristina PredaEndocrinology Department, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.
Giulia CocoOphthalmology Unit, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Assem NamazbayevaKazakh Eye Research Institute, Almaty, Kazakhstan.
Giuseppe GiannaccareEye Clinic, Department of Surgical Sciences, University of Cagliari, Via Università 40, 09124, Cagliari, Italy. giuseppe.giannaccare@unica.it.ORCID http://orcid.org/0000-0003-2617-0289
Daniel Constantin BranisteanuFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115, Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostoperative dry eye disease (DED) remains a frequent complication that can reduce patient satisfaction and surgical outcomes. Low-level light therapy (LLLT) is a non-invasive technology that has shown positive outcomes in managing DED. This study aimed to assess the prophylactic application of perioperative LLLT for improving ocular surface parameters and symptoms in consecutive patients undergoing cataract surgery.

methodsIn this prospective, double-masked, randomized sham-controlled study, patients scheduled for cataract surgery were randomized to receive either periocular LLLT or sham treatment 1 week before and 1 week after surgery. Ocular surface assessments, including Ocular Surface Disease Index (OSDI) questionnaire, tear film break-up time (BUT), Schirmer test type I, tear osmolarity, and corneal fluorescein staining (Oxford score), were performed preoperatively before the first treatment/sham session (T0), and postoperatively 1 week (T1) and 1 month postoperatively (T2). All patients received the same postoperative therapy.

resultsOut of 98 patients randomized to LLLT (50 patients) or sham treatment (48 patients), 89 patients (45 males, 44 females; mean age of 73.75 ± 7.95 years) completed the study. Unlike controls, the LLLT group showed significant improvements from T0 to T1 and T2 for OSDI scores (respectively, from 26.62 ± 15.42 to 15.53 ± 12.04 and 13.36 ± 11.69; p < 0.001) and BUT values (respectively, from 5.76 ± 3.99 to 6.69 ± 4.48 and 8.38 ± 4.53; p = 0.002), and from T0 to T2 for tear osmolarity (respectively, from 300.69 ± 14.19 mOsm/l to 296.11 ± 12.30 mOsm/l; p = 0.048). No significant differences were found in Schirmer test values within or between the two groups. No adverse effects were reported.

conclusionsPerioperative LLLT is a safe, well-tolerated, and effective treatment for preventing iatrogenic DED in cataract surgery. Integrating LLLT into the routine perioperative care may enhance patient satisfaction and overall outcomes in the setting of cataract surgery. CLINICAL TRIAL REGISTRATION NUMBER: NCT07067294, retrospectively registered on 05.07.2025.

Indexed as

Cataract surgeryDry eye diseaseLow-level light therapyOcular surface

Identifiers

PMID40849606
PMCPMC12413350

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.