ArticleCommunications biology2025
The ROS-FOXO pathway mediates broad-spectrum detoxification of acaricides in Tetranychus cinnabarinus.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
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- HcEcR Regulates Chitin Biosynthesis via 20E Signaling Rather Than Direct Transcriptional Activation in Hyphantria cunea Larvae.Archives of insect biochemistry and physiology · 2026Article
- Insights into the changes of soil microorganism communities and carbon cycle metabolic functions caused by the application of L-glufosinate-ammonium.Frontiers in microbiology · 2026Article
- 7,8-dihydroxyflavone attenuates NIH IIIA subtype chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) via TrkB/AKT/SIRT3 signaling activation.Translational andrology and urology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Arthropods have evolved advanced metabolic detoxification pathways that have helped them adapt to complex stresses induced by plant secondary metabolites and synthetic pesticides. Nonetheless, how xenobiotics induce the suite of intracellular metabolic changes important for detoxification in arthropods remains unexplored. In this study, we found that the ancient oxidative stress signaling pathway has adapted to transmit the detoxification signal in T. cinnabarinus, where accumulation of reactive oxygen species (ROS) plays a crucial role in initiating detoxification metabolism. Acaricides exposure led to ROS accumulation, resulting in the activation of Forkhead box O (FOXO) that in turn upregulates the expression of downstream xenobiotic sensors, including CncC, AhR, and HR96. These xenobiotic sensors then upregulate the expression of downstream detoxification genes, helping mites metabolically detoxify acaricides. This study reveals a cascade-amplifying mechanism for broad-spectrum detoxification in T. cinnabarinus that is initiated through ROS-FOXO triggering broad-spectrum detoxification of xenobiotics. These findings further elucidate the adaptive evolution of arthropods and suggest new avenues for novel pesticides and pest control.
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Registered trials
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