ArticlePharmacoEconomics - open2025
Identifying Potential Gaps in Care for Patients with Higher-Risk Myelodysplastic Syndromes in a Large US Health System.
Article in PharmacoEconomics - open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigher-risk myelodysplastic syndromes (HR-MDS) may be difficult to diagnose because patients present with nonspecific signs and symptoms. This can prolong diagnosis, even though disease progression can occur quickly in HR-MDS.
objectivesThis study identified places along the care journey where there are gaps in care in the identification, testing, diagnosis, and treatment of insured US patients with HR-MDS.
methodsThis retrospective study utilized nationally representative US administrative claims and linked socioeconomic and social determinants of health (SDoH) data to characterize newly diagnosed patients with HR-MDS between 1 January 2017 and 30 April 2022.
resultsThe study included 1710 patients, of which a large proportion experienced some level of unmet need for modifiable SDoH characteristics. The median time between first sign or symptom and HR-MDS diagnosis was nearly the full look-back period of 12 months. Fewer than half of the patients received guideline-recommended treatment. Few patients had clinical trial participation.
conclusionsOpportunities to improve care include designing programs that support SDoH needs of patients (such as transportation access or social isolation), shortening the time between initial signs or symptoms and diagnosis and improving access to clinical trial participation.
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