ArticleDiscover oncology2025
Exploring the multifaceted roles of glutamate oxaloacetate transaminase 1 as a biomarker and therapeutic target in colorectal cancer and pan-cancer analyses.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- SFTA2 reduced colorectal cancer ferroptosis promoting metastasis through regulating EMT transition by degradation of Nrf2.Food & nutrition research · 2026Article
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7 authors.
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Abstract
Colorectal cancer (CRC) is a global health issue requiring novel diagnostic and therapeutic approaches to improve patient outcomes. Glutamate oxaloacetate transaminase 1 (GOT1) plays a crucial role in metabolism and is associated with various cancers. However, its expression and potential as a diagnostic marker in CRC have not been thoroughly investigated. We analysed The Cancer Genome Atlas data on GOT1 normalised to transcripts per million. We used tools such as Gene Expression Profiling Interactive Analysis 2, logistic regression, receiver operating characteristic analysis, Sieber algorithm for immune detection, immune checkpoint gene correlation, cBioPortal analysis, and genomic sensitivities of cancers from the Genomics of Drug Sensitivity in Cancer and Cancer Therapeutics Response Portal to evaluate the association of GOT1 with CRC. GOT1 expression significantly varied across cancer types, showing high diagnostic value in colon adenocarcinoma and rectal adenocarcinoma. Moreover, it correlated with immune cells, such as CD8
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