Evidence map›Paper›PMID 40849548›Full record

ArticleBiogerontology2025

Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms.

Taili Zhao, Yunhua Hou, Chuanjiao Feng, Rui Zhao, Honghua Li, Peipei Zhao, Mengmeng Wang, Jingli Ren, Yiwei Meng, Kuidong Xu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Taili Zhao *School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Yunhua Hou *School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Chuanjiao FengBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Rui ZhaoBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Honghua LiState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, 276005, China.
Peipei ZhaoBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Mengmeng WangBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Jingli RenBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Yiwei MengBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Kuidong XuBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China.
Jia LiuSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Xin YinSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. yinxin@sdas.org.
Guimin ZhangState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, 276005, China. lunanzhangguimin@yeah.net.
Jingchun YaoState Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd, Linyi, 276005, China.
Xuekui XiaSchool of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. xiaxk@sdas.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional Chinese Medicine (TCM), as a globally recognized phytomedicinal approach, has made significant contributions to healthcare and anti-aging research worldwide. Jingfang Granule (JFG), an established TCM preparation in China, was demonstrated to exert effects on prolonging lifespan and healthspan via the Caenorhabditis elegans model in this study. We employed RNA-seq analysis to investigate the complex genetic interactions through which JFG extends the lifespan of C. elegans. We observed that administering JFG to adult nematodes increased the transcription levels of extracellular matrix (ECM)-related genes (including collagen genes), reproduction-related genes (e.g., egg-1, lin-41), and stress-activated transcription factor-1 (atfs-1). JFG treatment slowed down the functional degradation of organs, such as the cuticle, reproductive system, and mitochondria, leading to enhanced innate immunity and fecundity. Our findings demonstrate that JFG protects nematodes from age-related physiological decline and extends both lifespan and healthspan. This study not only highlights the effects of JFG on delaying aging but also provides a deep understanding of the genetic interactions underlying its anti-aging benefits.

Indexed as

Caenorhabditis elegansLongevityAgingAnimalsCaenorhabditis elegans ProteinsRNA-SeqSequence Analysis, RNACaenorhabditis elegans ProteinsCaenorhabditis elegansFecundityInnate immunityJingfang GranuleLifespan and healthspanMitochondrial function

Identifiers

PMID40849548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.