ArticleJournal of health, population, and nutrition2025
Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES.
Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Reframing Benign Prostatic Hyperplasia as a Cardiometabolic Condition: Should BPH Be Considered a Metabolic Disease?Reviews in cardiovascular medicine · 2026Article
- Cumulative of c-reactive protein-triglyceride glucose index exposure and risk of diabetes in middle-aged and older Chinese adults: findings from a national longitudinal cohort.Diabetology & metabolic syndrome · 2025Article
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7 authors.
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Abstract
backgroundThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a biomarker of lipid metabolism, has been used to predict cardiovascular disease incidence. However, its association with early-onset benign prostatic hyperplasia (BPH) remains unclear. This study aimed to investigate the relationship between NHHR and the risk of early-onset BPH.
methodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) in the United States between 2005 and 2008. NHHR was calculated as the ratio of non-HDL-C to HDL-C. Weighted multivariable logistic regression models were used to assess the association after adjusting for potential confounders.
resultsA total of 530 participants were included, with a median onset age of 60 years. Participants were divided into early-onset and late-onset BPH groups based on the median age. The early-onset group had higher rates of current smoking, education level, poverty-income ratio (PIR), BMI, NHHR, and total cholesterol compared to the late-onset group. After full adjustment, elevated NHHR was significantly associated with increased odds of early-onset BPH (OR = 1.35; 95% CI 1.09-1.68; P = 0.010). Additionally, higher NHHR was associated with a younger age of BPH onset (exp(β) = 0.17; 95% CI 0.07-0.42; P < 0.001). Subgroup analysis showed that this association was observed in most subgroups.
conclusionElevated NHHR is positively associated with early-onset BPH. Further prospective studies are needed to explore the role of lipid metabolism in prostate disease.
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