ArticleBMC geriatrics2025
Syncope is associated with multidimensional frailty in older adults.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultidimensional frailty and syncope are common in older adults, yet their relationship remains unclear.
methodsThis retrospective multicenter study, involving outpatients who underwent Comprehensive Geriatric Assessment, aims to evaluate the relationship between frailty and syncope. Patients were classified as fit/light frail, moderate frail or severe frail based on their fr-AGILE score. Patients reporting one or more episodes of syncope were referred to “Syncope and Fall Unit” and evaluated according to the recommendations of the European Society of Cardiology. Syncope episodes were classified in cardiac, reflex, orthostatic and of unknown origin. Multiple logistic regression analysis was employed to determine the association between the frailty score and syncope, independent of age, sex, comorbidity, and polypharmacy.
resultsAmong 560 patients (mean age 77.7 ± 6.9 years, 54.5% female), 107 reported experiencing syncopal episodes. Patients with history of syncope had a higher prevalence of orthostatic hypotension (41.1% vs. 18.8%, p = 0.001) and a higher fr-AGILE score (6.5 ± 2.0 vs. 5.4 ± 1.9, p = 0.001). Multivariate logistic regression analysis, adjusted for age, sex, comorbidity, and number of medications, showed that frailty, estimated by the fr-AGILE score, was associated with an increased risk of syncope (OR for each unit increase in fr-AGILE: 1.468, 95% CI: 1.276–1.690, p = 0.001). Frailty was associated with syncope, particularly cases of undetermined origin, but not with cardiac syncope.
conclusionsThe fr-AGILE score identifies patients at high risk of syncope. Frailty is strongly associated with non-cardiac syncope and with cases where a pathophysiological cause of the syncopal event could not be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.