Evidence map›Paper›PMID 40849435›Full record

ArticleNature communications2025

Molecular engineering of melanin for enhanced biological γ-ray protection.

Ruotong Deng, Wei Chen, Hanjie Zhu, Yuxi Li, Yining Ou, Jian Wang, Qing Ruan, Xuanying Zhang, Junbo Zhang, Yongxian Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruotong DengKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Wei ChenKey Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Hanjie ZhuSchool of Physics and Astronomy, Beijing Normal University, Beijing, 100875, China.
Yuxi LiKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Yining OuKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Jian WangKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Qing RuanKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Xuanying ZhangKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Junbo ZhangKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Yongxian ZhangDepartment of Radiology, Beijing Tongren Hospital, Beijing, 100730, China.
Yantao NiuDepartment of Radiology, Beijing Tongren Hospital, Beijing, 100730, China.
Zhubin HuState Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai, 200062, China.
Chunlei ZhangSchool of Physics and Astronomy, Beijing Normal University, Beijing, 100875, China.
Huaping XuKey Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, China. xuhuaping@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-7530-7264
Wei CaoKey Laboratory of Radiopharmaceuticals of the Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China. caowei@bnu.edu.cn.ORCID http://orcid.org/0000-0002-5048-7991

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22471021
6 · The paper itself

Abstract

The escalating utilization of ionizing radiation across medicine and industry underscored the paramount urgency of effective radioprotective materials. Conventional materials such as lead and concrete are widely used, and lead-free materials have also emerged to solve the problems of cumbersome and toxic lead, such as metal-containing micro/nano materials and polymers. Nevertheless, there is still a significant challenge in meeting the urgent need for lightweight and biocompatible alternatives. To tackle this challenge, this work utilizes molecular engineering of melanin to develop a panel of metal-free melanin materials with enhanced conjugation, heightened physical shielding against radiation and effective antioxidant properties. Furthermore, engineered melanin materials demonstrated in vivo γ-ray protection, increasing mice survival from ~12% to 100% after 6 Gy total body irradiation.

Indexed as

Gamma RaysMelaninsRadiation ProtectionRadiation-Protective AgentsAnimalsAntioxidantsHumansMiceWhole-Body IrradiationAntioxidantsMelaninsRadiation-Protective Agents

Identifiers

PMID40849435
PMCPMC12375129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.