Evidence map›Paper›PMID 40849431›Full record

ArticleNPJ Parkinson's disease2025

Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes.

Dongliang Cheng, Junyan Wen, Nan Ding, Zhenpeng Duan, Biqing Lin, Yunjun Yang, Yaozhong Wu, Hang Wang, Jincheng Ma, Jialu Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dongliang Cheng *Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Junyan Wen *Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nan DingDepartment of Neurology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Zhenpeng DuanDepartment of Neurology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Biqing LinDepartment of Neurology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Yunjun YangDepartment of Radiology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Yaozhong WuDepartment of Radiology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Hang WangDepartment of Radiology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Jincheng MaDepartment of Radiology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Jialu ZhangMR Research, GE Healthcare, Beijing, China.
Zhifeng XuDepartment of Radiology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Hai ZhaoDepartment of Radiology, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, China.
Yulin LiuDepartment of Rehabilitation Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China. 453373681@qq.com.
Ge WenMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. wenge@smu.edu.cn.

Funding

Foshan 14th Five-Year Plan Key Discipline Foundation No. FSGSP145036National Natural Scientific Foundation of China No. 82172012
6 · The paper itself

Abstract

Alterations in brain volume and subcortical myelin content (MyC) between tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes of Parkinson's (PD) disease remain unclear. This study investigated whole-brain volume and subcortical myelin content differences among PD motor subtypes using synthetic MRI. Ninety-two PD patients (39 TD and 53 PIGD) and 39 healthy controls were included. ANCOVA identified that PD patients exhibited reduced gray matter, white matter, and MyC, with no distinct atrophy patterns between TD and PIGD. Most subcortical nuclei showed decreased myelin, while PIGD presented more extensive alterations and increased bilateral caudate myelin; TD exhibited asymmetric thalamic myelin changes, with lateralized increases and decreases. Significant MyC differences in the left caudate and right GPi were observed between TD and PIGD. Synthetic MRI-derived parameters provide insights into whole-brain atrophy patterns and dynamic myelin changes in PD, contributing to a deeper understanding of PD subtypes.

Identifiers

PMID40849431
PMCPMC12375011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.