Evidence map›Paper›PMID 40849417›Full record

ArticleNPJ Parkinson's disease2025

Alterations of the skin microbiome in multiple system atrophy: a pilot study.

Daji Chen, Lang Sun, Linlin Wan, Zhao Chen, LinLiu Peng, Jinzi Peng, Riwei Ouyang, Xiafei Long, Kefang Du, Xiao Dong and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daji Chen *Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Lang Sun *Department of Medical Microbiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Linlin WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
LinLiu PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jinzi PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Riwei OuyangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xiafei LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Kefang DuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xiao DongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xiaokang WuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xinying XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Ruqing HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Rong QiuSchool of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China. jianghong73868@csu.edu.cn.

Funding

Central South University Research Program of Advanced Interdisciplinary Study 2023QYJC010China Postdoctoral Science Foundation 2024M753690Furong Lab Research Project 2023SK2084Major Scientific Research Project for High-level Health Talent in Hunan Province R2023047National Key Research and Development Program of China 2021YFA0805200National Natural Science Foundation of China 82171254National Natural Science Foundation of China 82301628National Natural Science Foundation of China 82371272National Natural Science Foundation of China 82401496Natural Science Foundation of Hunan Province 2024JJ3050Natural Science Foundation of Hunan Province 2024JJ6493Natural Science Foundation of Hunan Province 2024JJ6638Postdoctoral Fellowship Program of CPSF GZB20230870Science and Technology Innovation Program of Hunan Province 2022RC1027
6 · The paper itself

Abstract

Multiple system atrophy (MSA) alters skin physiology, potentially impacting skin microbiota. This pilot study investigated whether skin microbiota differs in MSA and whether these differences relate to disease severity. Using 16S rRNA sequencing of cervical and axillary sites in MSA, Parkinson's disease, and controls, we identified distinct microbial patterns among groups. These patterns allowed cohort classification and showed strong associations with clinical symptoms, suggesting disease-related microbial alterations in MSA.

Identifiers

PMID40849417
PMCPMC12375060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.