Evidence map›Paper›PMID 40849391›Full record

SynthesisPediatric surgery international2025

Serum matrix metalloproteinase-7 (MMP-7) as a Biomarker for differentiating biliary atresia from neonatal hepatitis: evidence synthesis through systematic review and meta-analysis.

Prativa Choudhury, Anjan Kumar Dhua, Vishesh Jain, Devendra Kumar Yadav, Teg Rabab Singh, Masarrat Afroz, Vikas Dhikav, Sandeep Agarwala, Prabudh Goel

Abstract readSystematic ReviewMeta-Analysis
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In one paragraph

Synthesis in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Prativa ChoudhuryDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Anjan Kumar DhuaDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Vishesh JainDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Devendra Kumar YadavDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Teg Rabab SinghDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Masarrat AfrozDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Vikas DhikavDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Sandeep AgarwalaDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India.
Prabudh GoelDepartment of Paediatric Surgery, All India Institute of Medical Sciences, Room No. 769, 7thFloor, MC Block, New Delhi, India. drprabudhgoel@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBiliary atresia (BA) requires timely differentiation from neonatal hepatitis (NH) and early surgery for optimal outcomes. This systematic review and meta-analysis evaluated the diagnostic performance of serum Matrix metalloproteinase-7 (MMP-7) as a biomarker for differentiating BA from NH.

methodsThe PRISMA-DTA compliant synthesis was based upon primary data available till date, assessing the role of MMP-7 in diagnosing BA. Studies reporting diagnostic accuracy metrics were included. Pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR) and area under the summary receiver operating characteristic (SROC) curve were calculated.

resultsTwenty-four studies (7298 participants: 3301 BA, 2,930 NH and 1067 controls) were analysed. The serum MMP-7 values ranged from 1.2 to 10.3 ng/mL in controls, 1.88-12.57 ng/mL in NH and 10.26-121.1 ng/mL in BA, with interquartile ranges spanning 1.08-25.3, 0.78-34.0 and 3.38-368.0 ng/mL, respectively. Median serum MMP-7 levels were consistently higher in BA vis-a-vis NH and the control population. Pooled sensitivity and specificity of MMP-7 as a diagnostic biomarker were 0.94 and 0.88, respectively. The DOR was 120.09 and the SROC AUC was 0.967.

conclusionSerum MMP-7 demonstrates excellent diagnostic accuracy for differentiating BA from NH. Further research should focus on assay standardization and age-specific reference ranges to optimize clinical utility.

Indexed as

Biliary AtresiaHepatitisMatrix Metalloproteinase 7BiomarkersDiagnosis, DifferentialHumansInfant, NewbornBiomarkersMatrix Metalloproteinase 7MMP7 protein, humanBiliary atresiaBiomarkerDiagnostic accuracyLiver fibrosisMatrix metalloproteinase-7MMP-7

Identifiers

PMID40849391

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