Evidence map›Paper›PMID 40849367›Full record

ArticleCommunications biology2025

Identification of conserved frontal neurophysiological markers of cognitive flexibility in humans and rats.

Andre Der-Avakian, Samuel A Barnes, Ty Lees, Hans S Schroder, Brian D Kangas, Samantha R Linton, Stefanie Nickels, Mykel A Robble, Micah Breiger, Ann M Iturra-Mena and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Andre Der-Avakian *Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Samuel A Barnes *Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Ty Lees *Department of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.ORCID http://orcid.org/0000-0002-7321-2704
Hans S SchroderDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Brian D KangasDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.ORCID http://orcid.org/0000-0002-4597-9801
Samantha R LintonDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.ORCID http://orcid.org/0000-0001-7512-1585
Stefanie NickelsDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.ORCID http://orcid.org/0000-0003-3788-2919
Mykel A RobbleDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Micah BreigerDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Ann M Iturra-MenaDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Rachel LobienDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Sarah PerloDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Emilia F CárdenasDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Genevieve P NowickiDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Zeyun WuDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, USA.
Hongyi PanDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, USA.
Daniel G DillonDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.ORCID http://orcid.org/0000-0002-1977-700X
James P KesbyQueensland Centre for Mental Health Research, Wacol, QLD, Australia.ORCID http://orcid.org/0000-0002-5814-8062
Jack BergmanDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
William A CarlezonDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA.
Victoria B RisbroughDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Eran MukamelDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3203-9535
Stefan LeutgebNeurobiology Section and Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3367-6536
Diego A PizzagalliDepartment of Psychiatry, McLean Hospital & Harvard Medical School, Belmont, MA, USA. dpizzaga@hs.uci.edu.ORCID http://orcid.org/0000-0002-7772-1143

Funding

Impact of TBI and Cognitive Decline on Alzheimer's Disease Brain-Derived Exosome CargoRF1AG079303 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RISBROUGH, VICTORIA B, RISSMAN, ROBERT · 2023 to 2023
$1.9M
Novel Cross-Species Neurophysiological Assays of Reward and Cognitive DomainsUH3MH109334 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2018 to 2021
$1.8M
Novel Cross-Species Neurophysiological Assays of Reward and Cognitive DomainsUH2MH109334 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2016 to 2017
$1.5M
NIA NIH HHS RF1 AG079303NIMH NIH HHS UH2 MH109334NIMH NIH HHS UH3 MH109334
6 · The paper itself

Abstract

Cognitive flexibility broadly describes behavioral alterations made in response to environmental changes and is fundamental for survival. While human and non-human animal assessments of cognitive flexibility are available, a systematic cross-species comparison of behavioral, neurophysiological, and computational markers of cognitive flexibility has not been reported. Using versions of a probabilistic reversal learning task aligned between humans and rats, electroencephalogram recordings reveal a frontal reward positivity (RewP) associated with unexpected reward outcomes. Reinforcement Q-learning models of both species' task behavior reveal that prediction error (PE) magnitude was significantly related to RewP amplitude. The stimulant drug modafinil alters PEs in rats without affecting the RewP in either species. These findings reveal analogous neurophysiological markers associated with PEs in humans and rats using equivalent tasks and identical computational analyses. This translational approach may improve the predictive validity of tests for novel pharmacotherapies and accelerate neuropsychiatric treatment by assessing neural mechanisms conserved across species.

Indexed as

CognitionFrontal LobeReversal LearningAdultAnimalsBehavior, AnimalCognitive FlexibilityElectroencephalographyFemaleHumansMaleModafinilRatsRewardSpecies SpecificityYoung AdultModafinil

Identifiers

PMID40849367
PMCPMC12375130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.