Evidence map›Paper›PMID 40849043›Full record

ArticleBiomedical journal2026

Occlusal disharmony attenuates inhibitory synaptic transmission in the medial prefrontal cortex and contributes to anxiety.

Juan Li, Jiayao Zhang, Ming Xu, Qi Zhang, Weicai Liu

Abstract read
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In one paragraph

Article in Biomedical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juan LiShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Prosthodontics, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, China.
Jiayao ZhangShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Prosthodontics, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, China.
Ming XuShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Prosthodontics, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, China.
Qi ZhangShanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Shanghai Changning Mental Health Center, Shanghai, China. Electronic address: ion_zhangqi@126.com.
Weicai LiuShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Prosthodontics, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai, China. Electronic address: vogi@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been well-validated that Occlusal Disharmony (OD) induces negative emotions, especially anxiety. While it leads to considerable frustration for both doctors and patients, its underlying mechanisms remain unclear, and effective treatment has been lacking. The present study aims to explore the pathological mechanisms of OD induced anxiety and to find a straightforward yet effective treatment strategy for this ostensibly intricate clinical phenomenon. MATERIAL AND

methodsOD mice were established through binding a metal tube to their right mandibular incisor. Then, the mental state of the mice was assessed by various behavioral experiments. Additionally, the mood of OD mice was also evaluated similarly before and after the injection of mifepristone. Furthermore, neuronal excitability in the mPFC was examined by immunofluorescence and electrophysiology, with the potential mechanisms investigated through Western blotting.

resultsOD mice exhibited anxiety-like behavior, and the administration of mifepristone, an anxiolytic drug, could alleviate it. Subsequently, an increase in neuronal excitability was observed, accompanied by a reduction in the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs) in the medial prefrontal cortex (mPFC). In addition, the expression of erb-b2 receptor tyrosine kinase 4 (ERBB4) and neuregulin 1 (NRG1), proteins associated with inhibitory neurotransmitter release, were found to be significantly downregulated in the mPFC.

conclusionOD attenuates GABAergic synaptic transmission in the mPFC, which may be the neural mechanism of anxiety caused by OD. But this phenomenon could be effectively alleviated by anti-anxiety treatment.

Indexed as

AnxietyMalocclusionPrefrontal CortexAnimalsAnti-Anxiety AgentsDisease Models, AnimalInhibitory Postsynaptic PotentialsMaleMiceMifepristoneNeuregulin-1Patch-Clamp TechniquesReceptor, ErbB-4Synaptic TransmissionAnti-Anxiety AgentsErbb4 protein, mouseMifepristoneNeuregulin-1Nrg1 protein, mouseReceptor, ErbB-4AnxietyElectrophysiologicalGABAMifepristoneOcclusal disharmonyThe medial prefrontal cortex

Identifiers

PMID40849043
PMCPMC13226911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.