Evidence map›Paper›PMID 40848911›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026

Diagnostic and Management Review of Gastric and Supragastric Belching, Aerophagia, and Rumination Syndrome.

Kelli Liu, Erin Walsh, David Katzka, Albert J Bredenoord, Mary Clarke, Livia Guadagnoli, Liza Blumenfeld, Rena Yadlapati

Abstract readReview
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kelli LiuDepartment of Medicine, University of California San Diego, La Jolla, California.
Erin WalshDepartment of Otolaryngology, University of California San Diego, La Jolla, California.
David KatzkaDivision of Gastroenterology, Columbia University Medical Center, New York, New York.
Albert J BredenoordDepartment of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Mary ClarkeDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Diego, La Jolla, California.
Livia GuadagnoliDivision of Gastroenterology and Hepatology, Feinberg School of Medicine, Chicago, Illinois.
Liza BlumenfeldDepartment of Otolaryngology, University of California San Diego, La Jolla, California.
Rena YadlapatiDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Diego, La Jolla, California. Electronic address: ryadlapati@health.ucsd.edu.

Funding

The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal RefluxR01DK139089 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rena Hiren Yadlapati · 2024 to 2026
$2.0M
Mechanism Guided Therapy for Laryngopharyngeal RefluxK23DK125266 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2021 to 2025
$963k
NIDDK NIH HHS K23 DK125266NIDDK NIH HHS R01 DK139089
6 · The paper itself

Abstract

Supragastric belching and rumination syndrome are distressing and potentially debilitating gastrointestinal disorders. Though related, these conditions are distinct from aerophagia and excessive gastric belching. Although diagnostic standards and effective treatment strategies are emerging, formal guideline-directed treatment and validated measurement tools to demonstrate efficacy of interventions are lacking. This narrative review synthesizes current evidence in presentation, pathophysiology, diagnosis, and treatment through a systematic search of the literature over the past 2 decades. Supragastric belching, rumination syndrome, excessive gastric belching, and aerophagia have distinct physiologies and vary in symptomatic and psychosocial burden. Although clinical evaluation plays a key role in diagnosis, supragastric belching and rumination syndrome can be objectively confirmed through pH-impedance testing or high-resolution impedance manometry. Supragastric belching and rumination syndrome can be managed effectively with psychoeducation and behavioral treatment strategies. These strategies are underexplored in excessive gastric belching, for which baclofen remains a primary therapy. Aerophagia is rarely symptomatic, and management is comprised of behavioral modifications. Further studies evaluating multidisciplinary behavioral therapy strategies with validated outcome measurement tools are needed to develop management guidelines and improve the lives of patients with these complex conditions. Evaluation for secondary causes is key to well-rounded, effective treatment.

Indexed as

AerophagyDisease ManagementEructationRumination SyndromeBehavior TherapyHumansManometryEructationGERDIneffective Esophageal MotilityRegurgitation

Identifiers

PMID40848911
PMCPMC13222039

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.