Evidence map›Paper›PMID 40848898›Full record

ArticleJournal of advanced research2026

Genome-wide characterization and adaptive evolution of favorable gibberellin 2-oxidase alleles contributing to wheat agronomic traits.

Yingjie Bian, Jiayu Dong, Lingli Li, Dengan Xu, Xiuling Tian, Yan Dong, Jianqi Zeng, Qiang Cao, Yachao Dong, Lina Xie and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yingjie BianState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China; College of Agronomy, Northwest A&F University, Yangling 712100 Shaanxi, China.
Jiayu DongState Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Lingli LiState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Dengan XuCollege of Agronomy, Qingdao Agricultural University, Qingdao 266109, China.
Xiuling TianState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Yan DongCrop Research Institute, Ningxia Academy of Agricultural and Forestry Sciences, 490 Huanghe Road, Yinchuan 750002 Ningxia, China.
Jianqi ZengState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Qiang CaoState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Yachao DongState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Lina XieState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Bingyan LiuState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Kejia QuState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Yuheng ChaoState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Rui CheState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Jindong LiuState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Yong ZhangState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Xianchun XiaState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Daojie SunCollege of Agronomy, Northwest A&F University, Yangling 712100 Shaanxi, China. Electronic address: Sunwheat@nwafu.edu.cn.
Fei LuState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: flu@genetics.ac.cn.
Zhonghu HeState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: hezhonghu02@caas.cn.
Shuanghe CaoState Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: caoshuanghe@caas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGibberellins are essential phytohormones that regulate plant growth and development. Gibberellin 2-oxidases (GA2oxs) deactivate bioactive gibberellin isoforms and many GA2ox genes have been validated as key regulators of agronomic traits in model plants and crops. However, there are few studies on GA2ox genes in wheat, one of the most important staple crops.

objectiveThis study aims to identify favorable alleles of wheat GA2ox genes (TaGA2oxs) and assess their application in wheat improvement.

methodsWe developed an efficient pipeline that integrates population genomics, transgene, transcriptome and evolutionary analyses to systemically dissect genetic effects of TaGA2ox variations on agronomic traits.

resultsWe identified 40 TaGA2oxs by genome-wide in silico cloning, defined 25 C19-type and 15 C20-type members based on sequence similarity and specified TaGA2ox family expansion by genomic polyploidization, duplication and translocation events. Functional TaGA2oxs were predicted by spatiotemporal expression assays, genetic meta-analysis and genome microsynteny-based phylogeny. We retrieved 52 major haplotypes at 19 TaGA2ox loci based on genome resequencing data for representative wheat cultivars and developed diagnostic molecular markers. In addition to previously-validated favorable haplotypes Rht12b and Rht24b that reduce plant height and have no yield penalty, eight new favorable haplotypes of TaGA2oxs were identified by marker-trait association analysis. Among them, TaGA2ox8-B1-1_hap1, TaGA2ox8-B1-2_hap1 and TaGA2ox8-B1-3_hap1 formed a tandem duplicate gene cluster associated with reduced plant height and increased grain yield. TaGA2ox8-B1-2 as proof of concept was functionally validated to modulate major agronomic traits by transgene assays; its downstream genes and effect on gibberellin homeostasis were also identified by transcriptome, enzyme activity and hormone quantitative analyses. We further traced the origin, spread and distribution of favorable haplotypes to clarify their evolutionary history and application prospects.

conclusionThese findings not only provide valuable genetic resources and molecular tools for wheat improvement but also broaden genetic insight into gibberellin-mediated wheat morphogenesis, acclimation and yield formation.

Indexed as

Mixed Function OxygenasesPlant ProteinsTriticumAllelesEvolution, MolecularGene Expression Regulation, PlantGenome, PlantGibberellinsPhylogenygibberellin 2-dioxygenaseGibberellinsMixed Function OxygenasesPlant ProteinsAgronomic traitsEvolutionFavorable variationTaGA2oxTriticum aestivum

Identifiers

PMID40848898
PMCPMC13131445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.