Evidence map›Paper›PMID 40848299›Full record

ArticleACS chemical biology2025

Design of Hyperglycosylated Zika Virus E Proteins that Focus Antibody Recognition on the Complex E Dimer Epitope.

Margarette C Mariano, Matthew Gregory Hvasta, Kimberly A Dowd, Wei-Chiao Huang, Helen S Jung, Lamount R Evanson, George I Georgiev, Julia C Frei, Jonathan F Lovell, Theodore C Pierson and 2 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Margarette C MarianoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-8331-0156
Matthew Gregory HvastaDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.
Kimberly A DowdArbovirus Immunity Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, United States.
Wei-Chiao HuangDepartment of Biomedical Engineering, University at Buffalo, Buffalo, New York 14260, United States.
Helen S JungDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0003-0863-6460
Lamount R EvansonDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
George I GeorgievDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Julia C FreiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, Buffalo, New York 14260, United States.ORCID 0000-0002-9052-884X
Theodore C PiersonArbovirus Immunity Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, United States.
Brian KuhlmanDepartment of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States.
Jonathan R LaiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID 0000-0002-4863-0015

Funding

Project 5: mAb Development Flaviviruses and AlphavirusesU19AI181960 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S · 2024 to 2024
$46.7M
Medical Scientist Training ProgramT32GM149364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Myles H. Akabas · 2023 to 2026
$7.5M
Structure-based design of broad flavivirus immunogensR01AI158194 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI LAI, JONATHAN R. · 2021 to 2025
$3.7M
Structure based design of dengue subunit vaccines for inducing protective but not disease enhancing antibodiesR01AI161025 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Aravinda M. DeSilva, BRIAN A KUHLMAN · 2022 to 2026
$3.6M
Safe Antibody Prophylaxis and Therapy Against Dengue VirusU01AI077955 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S · 2008 to 2011
$3.4M
Training Program in Cellular and Molecular Biology and GeneticsT32GM145438 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CHARLES C QUERY · 2023 to 2026
$2.4M
Strategies for next-generation flavivirus vaccine developmentF30AI174788 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI JUNG, HELEN S · 2023 to 2025
$158k
NIAID NIH HHS F30 AI174788NIAID NIH HHS R01 AI158194NIAID NIH HHS R01 AI161025NIAID NIH HHS U01 AI077955NIAID NIH HHS U19 AI181960NIGMS NIH HHS T32 GM145438NIGMS NIH HHS T32 GM149364
6 · The paper itself

Abstract

Zika virus (ZIKV) and dengue virus serotypes 1-4 (DENV1-4) are flaviviruses spread by

Indexed as

Antibodies, ViralEpitopesViral Envelope ProteinsZika VirusAnimalsAntibodies, MonoclonalAntibodies, NeutralizingGlycosylationHumansMiceZika Virus InfectionAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesViral Envelope Proteins

Identifiers

PMID40848299
PMCPMC13064928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.