Evidence map›Paper›PMID 40848204›Full record

ReviewNeurosurgical review2025

Adenoid cystic carcinoma brain metastases treated with stereotactic radiosurgery: A single institution retrospective cohort study and comprehensive literature review.

Ahed H Kattaa, Yusuke S Hori, Paul M Harary, Amirhossein Akhavan-Sigari, Aroosa Zamarud, Amit R Persad, Armine Tayag, Louisa Ustrzynski, Sara C Emrich, David J Park and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ahed H KattaaDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Yusuke S HoriDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Paul M HararyDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Amirhossein Akhavan-SigariDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Aroosa ZamarudDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Amit R PersadDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Armine TayagDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Louisa UstrzynskiDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Sara C EmrichDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
David J ParkDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA.
Steven D ChangDepartment of Neurosurgery, Stanford University School of Medicine, 453 Quarry Road, Stanford, CA, 94304, USA. sdchang@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenoid cystic carcinoma (ACC) is a malignant neoplasm arising from the minor and major salivary glands that tend to spread by perivascular and perineural routes. Brain metastases (BM) secondary to ACC are extremely rare, and the standard management strategy has not been well reported due to the rarity. Notably, no previous study has specifically examined the efficacy of stereotactic radiosurgery (SRS) for BM from ACC. We retrospectively reviewed cases of BM from ACC treated with CyberKnife (CK) SRS at our institution between 1998 and 2024. A total of 40 lesions from 5 patients were included. Tumor control was defined based on radiological response to CK SRS as a complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) per response evaluation criteria in solid tumors (RECIST) guidelines. The median Follow-up duration was 11 months (Range: 3-51 months). The median age at treatment was 52 years with a male-to-female ration of 3:2. The median maximum diameter of the lesions was 7.mm. The median prescription dose delivered was 24 Gy. The treatment responses at the first follow-up were CR/PR/SD/PD: 9/19/12/0. At the last follow-up, 5 lesions had local progression, with one lesion at 39 months, and 4 lesions at 11 months after CK SRS, while 16 lesions remained CR. The cumulative 3-months, 6-months, and 12-months local control rates were 100%, 100%, and 89%, respectively. To date, this is the largest study examining the efficacy of SRS for ACC BM. Our results showed sufficient local control following the treatment.

Indexed as

Brain NeoplasmsCarcinoma, Adenoid CysticRadiosurgerySalivary Gland NeoplasmsAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAdenoid cystic carcinomaBrain metastasesCyberknife radiosurgeryCylindromaStereotactic radiosurgery

Identifiers

PMID40848204

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.