Evidence map›Paper›PMID 40848131›Full record

ArticleActa diabetologica2026

Increased expression of OX40 on peripheral CD4

Xingxing Fang, JiaJia Chen, Ling Lin, Feng Xu, Chen Fang, Ji Hu, Yimei Shan, Cuiping Liu

Abstract read
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Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xingxing FangDepartment of Nephrology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China.
JiaJia ChenDepartment of Nephrology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China.
Ling LinNantong Center for Disease Control and Prevention, Nantong, Jiangsu, China.
Feng XuDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China.
Chen FangDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Ji HuDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yimei ShanDepartment of General Practice, Affiliated Hospital 2 of Nantong University, 666 Shengli Road, Nantong, 226001, Jiangsu, China. shanyimei@126.com.ORCID http://orcid.org/0000-0002-0065-8983
Cuiping LiuJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 Ganjiang East Road, Suzhou, 215000, China. liucuiping1980@126.com.

Funding

National Natural Science Foundation of China 82070814Research Project of Nantong Municipal Health Commission MS2023091Scientific Research Project of Jiangsu Health Commission Z2022014
6 · The paper itself

Abstract

aimsAutoreactive memory T cells are considered to be a primary contributor to chronic islet inflammation in individuals with type 1 diabetes (T1D). OX40-expressing T cells not only facilitate and sustain the presence of CD4

methodsA total of 35 patients diagnosed with Type 1 diabetes and 40 healthy control individuals were enrolled in this study. Peripheral Blood Mononuclear Cells (PBMCs) were isolated from the study participants and analyzed by flow cytometry. Inflammatory cytokines in the plasma were quantitatively measured. The pancreatic islet autoantibodies as well as islet function were also evaluated.

resultsThe frequencies and the mean fluorescence intensity (MFI) of OX40 on CD4

conclusionsThe elevated expression of OX40 on CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDiabetes Mellitus, Type 1Memory T CellsReceptors, OX40AdolescentAdultAutoantibodiesCase-Control StudiesChildFemaleHumansImmunologic MemoryMaleYoung AdultAutoantibodiesReceptors, OX40TNFRSF4 protein, humanCentral memory T(Tcm) cellsEffector memory T(Tem) cellsOX40Type 1 diabetes

Identifiers

PMID40848131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.