Evidence map›Paper›PMID 40848125›Full record

ArticleAbdominal radiology (New York)2026

Clinical and imaging comparison of primary liver carcinosarcoma and sarcomatoid carcinoma.

Lun Lu, Ruiping Zhang, Xingpeng Pan, Helin Li, Guihong Nian, Yiping Liu, Yayuan Feng, Ningyang Jia

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lun LuDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China.
Ruiping ZhangDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China.
Xingpeng PanDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China.
Helin LiDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China.
Guihong NianDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China.
Yiping LiuDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China. liuyiping108@126.com.
Yayuan FengDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China. Fengyayuan007@163.com.
Ningyang JiaDepartment of Radiology, The Third Afffliated Hospital of Naval Medical University, Shanghai, China. ningyangjia@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrimary liver carcinosarcoma (CS) and sarcomatoid carcinoma (SC) are rare malignant tumors of the liver. Although the two tumors often overlap in clinical and imaging manifestations, there are currently no reports comparing the imaging features of these two tumors. Our study aims to compare the clinical characteristics and imaging features of these two tumors to further describe their distinct features, thereby enhancing understanding and diagnostic accuracy.

methodsA retrospective analysis was conducted on the clinical and imaging data of 17 patients with CS and 27 patients with SC diagnosed by surgical or needle biopsy between September 2010 and December 2024 at our hospital. The data were summarized and statistically analyzed.

resultsBoth groups were predominantly male, with a lower mean age (56.65 ± 11.82) in the CS group compared to the SC group (64.93 ± 8.15) (P = 0.01). Compared to the SC group, the CS group more commonly presented with hepatitis B, cirrhosis, and elevated AFP levels. Both groups were more commonly located in the right hepatic lobe, with larger tumors that were often solitary, irregularly shaped, and lobulated. Most tumors exhibited necrosis and hemorrhage. Calcification was observed in two cases in the CS group on CT scans. The tumor margins were predominantly indistinct, and the majority of tumors did not show a capsule. Approximately half of the patients in the SC group had lymph node involvement, which was significantly higher than in the CS group (P = 0.023). After contrast enhancement, all cases in both groups showed heterogeneous enhancement in the arterial phase. Regarding enhancement distribution, the CS group more commonly exhibited enhancement at the margins and in the solid components, while most cases in the SC group showed enhancement at the margins and in the septa. In terms of dynamic enhancement patterns, the CS group more commonly exhibited partial or complete regression in the delayed phase, while the SC group more commonly exhibited progressive or persistent enhancement in the delayed phase, with statistical significance (P = 0.042).

conclusionPatients in the SC group had significantly higher age and lymph node involvement than those in the CS group. In terms of tumor enhancement patterns, the CS group primarily exhibited delayed-phase regression or partial regression, while the SC group primarily exhibited delayed-phase persistent or progressive enhancement.

Indexed as

CarcinosarcomaLiver NeoplasmsTomography, X-Ray ComputedAgedDiagnosis, DifferentialFemaleHumansLiverMaleMiddle AgedRetrospective StudiesComputed tomographyMagnetic resonance imagingPrimary liver carcinosarcomaPrimary liver sarcomatoid carcinoma

Identifiers

PMID40848125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.