Evidence map›Paper›PMID 40848062›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Proton versus photon radiation therapy for pediatric medulloblastomas: a systematic review and meta-analysis.

Lucca B Palavani, Pedro G L B Borges, Gabriel Semione, Marcio Yuri Ferreira, Paulo Victor Zattar Ribeiro, Jhon E Bocanegra-Becerra, Camila Vilhena, Leonardo B O Brenner, Dan Zimelewicz Oberman, Erion Junior de Andrade and 4 more

Abstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lucca B PalavaniMax Planck University Center, Indaiatuba, São Paulo, Brazil.
Pedro G L B BorgesFundação Técnico-Educacional Souza Marques, Rio de Janeiro, Rio de Janeiro, Brazil.
Gabriel SemioneUniversity of West of Santa Catarina, Joaçaba, Santa Catarina, Brazil.
Marcio Yuri FerreiraDepartment of Neurosurgery, Lenox Hill Hospital/Northwell Health, New York, NY, USA.
Paulo Victor Zattar RibeiroDepartment of Medical Genetics, State University of São Paulo, Ribeiro Preto, Brazil.
Jhon E Bocanegra-BecerraSchool of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
Camila VilhenaMax Planck University Center, Indaiatuba, São Paulo, Brazil.
Leonardo B O BrennerDepartment of Neurosurgery, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.
Dan Zimelewicz ObermanDepartment of Neurosurgery, Hospital de Força Aérea Do Galeão, Rio de Janeiro, Brazil.
Erion Junior de AndradeDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, USA.
S Farzad MaroufiDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Marcio S RassiDivision of Neurosurgery, Department of Surgery, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Raphael BertaniDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Cleiton FormentinDepartment of Neurosurgery, State University of Campinas, Campinas, SP, Brazil. cleitonformentin@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe rapid development of technologies that allow a more precise radiation-based treatment has constantly changed the current scenario of malignant central nervous system diseases. This study aimed to compare different complications and survival rates of pediatric patients with medulloblastomas treated with proton radiation therapy (PBRT) and photon radiation therapy (XRT).

methodsWe performed a systematic review and comparative meta-analysis. A total of 1319 studies were screened, and nine cohorts including 889 patients (509 PBRT and 380 XRT) were included. The primary endpoint was the overall survival in 5 years. Complications were analyzed separately. A random-effects model was used to calculate the odds ratios (ORs), with 95% confidence intervals (CIs) and a significance level of 5%.

resultsPrimary endpoint overall 5-year survival showed no statistically significant difference between PBRT and XRT treatments (351 patients; OR 0.86 [0.46; 1.62] 95% CI; p = 0.73; I

conclusionThis systematic review and meta-analysis identified that the use of PBRT carries a lower likelihood of minor complications when compared to XRT for pediatric medulloblastomas. This suggests that PBRT can achieve comparable safety and effectiveness to XRT while delivering lower radiation doses to various tissues and organs.

Indexed as

Cerebellar NeoplasmsMedulloblastomaPhotonsProton TherapyChildHumansMedulloblastomaMeta-analysisPhoton radiation therapyProton radiation therapyTreatment outcome

Identifiers

PMID40848062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.